{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:44:13Z","timestamp":1760921053942,"version":"build-2065373602"},"reference-count":8,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T00:00:00Z","timestamp":1409875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002460","name":"Chung-Ang University","doi-asserted-by":"crossref","award":["2013"],"award-info":[{"award-number":["2013"]}],"id":[{"id":"10.13039\/501100002460","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>We developed a method for the simultaneous quantification of 7\u2010<jats:italic>O<\/jats:italic>\u2010succinyl macrolactin A and its active metabolite, macrolactin A, in dog plasma. After protein precipitation with acetonitrile including flufenamic acid as an internal standard, 7\u2010<jats:italic>O<\/jats:italic>\u2010succinyl macrolactin A, macrolactin A, and flufenamic acid were chromatographed on a reverse\u2010phase C<jats:sub>18<\/jats:sub> analytical column. The mobile phase, consisting of 20\u00a0mM acetate buffer and acetonitrile, was eluted using a gradient program at 1\u00a0mL\/min, and the UV absorbance was measured at 230\u00a0nm. The retention times of 7\u2010<jats:italic>O<\/jats:italic>\u2010succinyl macrolactin A, flufenamic acid, and macrolactin A were 3.4, 4.8, and 6.9\u00a0min, respectively. The coefficient of variation in the assay precision for both substances was less than 6%, and the accuracy ranged from 96 to 105%. This method was used to measure the concentrations of 7\u2010<jats:italic>O<\/jats:italic>\u2010succinyl macrolactin A and macrolactin A in dog plasma following an intravenous administration of a single dose (25\u00a0mg\/kg) of 7\u2010<jats:italic>O<\/jats:italic>\u2010succinyl macrolactin A salt.<\/jats:p>","DOI":"10.1002\/jssc.201400438","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T20:52:58Z","timestamp":1407444778000},"page":"2833-2836","source":"Crossref","is-referenced-by-count":1,"title":["Simultaneous determination of 7\u2010<i>O<\/i>\u2010succinyl macrolactin A and its active major metabolite, macrolactin A in dog plasma using high\u2010performance liquid chromatography with UV detection"],"prefix":"10.1002","volume":"37","author":[{"given":"Eunyoung","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy Chung\u2010Ang University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beomsoo","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Pharmacy Catholic University of Daegu  Kyoungbuk South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010il","family":"Kwon","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chungnam National University  Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Seok","family":"Bang","sequence":"additional","affiliation":[{"name":"Graduate School of Clinical Pharmacy Sookmyung Women's University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wonku","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chung\u2010Ang University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-011-0117-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.5.1701-1709.2006"},{"key":"e_1_2_8_4_1","unstructured":"Chung S. 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Guidance for industry Bioanalytical methods validation."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201200367"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.598"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201301191"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.201400438","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.201400438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:16:35Z","timestamp":1760883395000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.201400438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,5]]},"references-count":8,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1002\/jssc.201400438"],"URL":"https:\/\/doi.org\/10.1002\/jssc.201400438","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"type":"print","value":"1615-9306"},{"type":"electronic","value":"1615-9314"}],"subject":[],"published":{"date-parts":[[2014,9,5]]}}}