{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:55:57Z","timestamp":1788054957874,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T00:00:00Z","timestamp":1420588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>A global chemical profiling based quality evaluation approach using ultra performance liquid chromatography with tandem quadrupole time\u2010of\u2010flight mass spectrometry was developed for the quality evaluation of three rhubarb species, including <jats:italic>Rheum palmatum<\/jats:italic> L., <jats:italic>Rheum tanguticum<\/jats:italic> Maxim. ex Balf., and <jats:italic>Rheum officinale<\/jats:italic> Baill. Considering that comprehensive detection of chemical components is crucial for the global profile, a systemic column performance evaluation method was developed. Based on this, a Cortecs column was used to acquire the chemical profile, and Chempattern software was employed to conduct similarity evaluation and hierarchical cluster analysis. The results showed <jats:italic>R. tanguticum<\/jats:italic> could be differentiated from <jats:italic>R. palmatum<\/jats:italic> and <jats:italic>R. officinale<\/jats:italic> at the similarity value 0.65, but <jats:italic>R. palmatum<\/jats:italic> and <jats:italic>R. officinale<\/jats:italic> could not be distinguished effectively. Therefore, a common pattern based on three rhubarb species was developed to conduct the quality evaluation, and the similarity value 0.50 was set as an appropriate threshold to control the quality of rhubarb. A total of 88 common peaks were identified by their accurate mass and fragmentation, and partially verified by reference standards. Through the verification, the newly developed method could be successfully used for evaluating the holistic quality of rhubarb. It would provide a reference for the quality control of other herbal medicines.<\/jats:p>","DOI":"10.1002\/jssc.201400971","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T19:19:18Z","timestamp":1418066358000},"page":"511-522","source":"Crossref","is-referenced-by-count":40,"title":["Global chemical profiling based quality evaluation approach of rhubarb using ultra performance liquid chromatography with tandem quadrupole time\u2010of\u2010flight mass spectrometry"],"prefix":"10.1002","volume":"38","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing P. R. 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