{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:48Z","timestamp":1786978128976,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>\n                    Paracetamol, caffeine and ibuprofen are found in over\u2010the\u2010counter pharmaceutical formulations. In this work, we propose two new methods for simultaneous determination of paracetamol, caffeine and ibuprofen in pharmaceutical formulations. One method is based on high\u2010performance liquid chromatography with diode\u2010array detection and the other on capillary electrophoresis with capacitively coupled contactless conductivity detection. The separation by high\u2010performance liquid chromatography with diode\u2010array detection was achieved on a C\n                    <jats:sub>18<\/jats:sub>\n                    column (250\u00d74.6 mm\n                    <jats:sup>2<\/jats:sup>\n                    , 5 \u03bcm) with a gradient mobile phase comprising 20\u2013100% acetonitrile in 40 mmol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    phosphate buffer pH 7.0. The separation by capillary electrophoresis with capacitively coupled contactless conductivity detection was achieved on a fused\u2010silica capillary (40 cm length, 50 \u03bcm i.d.) using 10 mmol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    3,4\u2010dimethoxycinnamate and 10 mmol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u03b2\u2010alanine with pH adjustment to 10.4 with lithium hydroxide as background electrolyte. The determination of all three pharmaceuticals was carried out in 9.6 min by liquid chromatography and in 2.2 min by capillary electrophoresis. Detection limits for caffeine, paracetamol and ibuprofen were 4.4, 0.7, and 3.4 \u03bcmol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    by liquid chromatography and 39, 32, and 49 \u03bcmol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    by capillary electrophoresis, respectively. Recovery values for spiked samples were between 92\u2013107% for both proposed methods.\n                  <\/jats:p>","DOI":"10.1002\/jssc.201401387","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T11:26:26Z","timestamp":1426159586000},"page":"1657-1662","source":"Crossref","is-referenced-by-count":98,"title":["Simultaneous determination of caffeine, paracetamol, and ibuprofen in pharmaceutical formulations by high\u2010performance liquid chromatography with UV detection and by capillary electrophoresis with conductivity detection"],"prefix":"10.1002","volume":"38","author":[{"given":"Rafael R.","family":"Cunha","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica Universidade Federal de Uberl\u00e2ndia  Av. 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