{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T09:32:16Z","timestamp":1776418336743,"version":"3.51.2"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AQSIQ Research Projects","award":["2014IK110"],"award-info":[{"award-number":["2014IK110"]}]},{"name":"AQSIQ Research Projects","award":["2010IK183"],"award-info":[{"award-number":["2010IK183"]}]},{"name":"Key Programs for Science and Technology Development","award":["2010Y0001"],"award-info":[{"award-number":["2010Y0001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>An ultra high performance liquid chromatography with tandem mass spectrometry method was established for the rapid and simultaneous analysis of seven antiviral drugs, amantadine, rimantadine, memantine, moroxydine, imiquimod, oseltamivir, and acyclovir, in chicken liver, muscle, and egg. Homogenized samples were extracted with trichloroacetic acid and acetonitrile solutions and then purified by cation\u2010exchange solid\u2010phase extraction. The target drugs were analyzed by liquid chromatography with a UPLC BEH Amide column (2.1 mm \u00d7 100 mm, 1.7 \u03bcm) coupled with a tandem mass spectrometer operating in the positive multiple\u2010reaction mode. A perfectly linear relationship was obtained within the concentration ranges of 0.5\u201320 \u03bcg\/L for acyclovir and 0.1\u201310 \u03bcg\/L for the other six antiviral drugs. The average recoveries of the seven antiviral drugs using four addition levels in chicken liver, muscle, and eggs were 82.67\u201390.10, 82.30\u201392.27, and 81.98\u201393.77%, respectively, and the acceptable coefficients of variation were 5.18\u20139.88, 4.84\u201311.2, and 42.8\u20139.95%, respectively. The detection limits and detection capabilities of the analysis method for the seven antiviral drugs were in the ranges of 0.04\u20130.64 and 0.11\u20130.78 \u03bcg\/kg, respectively. Additionally, an inter\u2010laboratory study among five laboratories further validated the method.<\/jats:p>","DOI":"10.1002\/jssc.201401461","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T07:19:46Z","timestamp":1426576786000},"page":"1784-1793","source":"Crossref","is-referenced-by-count":32,"title":["Simultaneous determination of antiviral drugs in chicken tissues by ultra high performance liquid chromatography with tandem mass spectrometry"],"prefix":"10.1002","volume":"38","author":[{"given":"ZhengCai","family":"Liu","sequence":"first","affiliation":[{"name":"Fujian Entry\u2010Exit Inspection &amp; Quarantine Bureau Fujian Provincial Key Laboratory of Inspection and Quarantine Technology Research  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Fujian Entry\u2010Exit Inspection &amp; Quarantine Bureau Fujian Provincial Key Laboratory of Inspection and Quarantine Technology Research  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minna","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Food Science Fujian Agriculture and Forestry University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YongHui","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian Entry\u2010Exit Inspection &amp; Quarantine Bureau Fujian Provincial Key Laboratory of Inspection and Quarantine Technology Research  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZhiJiao","family":"Su","sequence":"additional","affiliation":[{"name":"Fujian Entry\u2010Exit Inspection &amp; Quarantine Bureau Fujian Provincial Key Laboratory of Inspection and Quarantine Technology Research  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WHO Avian influenza fact sheet Geneva2011."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.04.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2007.08.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.05.006"},{"key":"e_1_2_7_6_1","first-page":"103","volume":"118","author":"Ghosh G. 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