{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:07:33Z","timestamp":1770962853599,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:00:00Z","timestamp":1441670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Chloropropanols are processing toxicants with a potential risk to human health due to the increased intake of processed foods. A rapid and efficient method for the determination of three chloropropanols in human plasma was developed using ultrasound\u2010assisted dispersive liquid\u2013liquid microextraction. The method involved derivatization and extraction in one step followed by gas chromatography with tandem mass spectrometry analysis. Parameters affecting extraction, such as sample pH, ionic strength, type and volume of dispersive and extraction solvents were optimized by response surface methodology using a pentagonal design. The linear range of the method was 5\u2013200 ng\/mL for 1,3\u2010dichloro\u20102\u2010propanol, 10\u2013200 ng\/mL for 2,3\u2010dichloro\u20102\u2010propanol and 10\u2013400 ng\/mL for 3\u2010chloropropane\u20101,2\u2010diol with the determination coefficients between 0.9989 and 0.9997. The limits of detection were in the range of 0.3\u20133.2 ng\/mL. The precision varied from 1.9 to 10% relative standard deviation (<jats:italic>n<\/jats:italic> = 9). The recovery of the method was between 91 and 101%. Advantages such as low consumption of organic solvents and short time of analysis make the method suitable for the biomonitoring of chloropropanols.<\/jats:p>","DOI":"10.1002\/jssc.201500468","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T06:29:03Z","timestamp":1437546543000},"page":"3428-3434","source":"Crossref","is-referenced-by-count":7,"title":["Response surface methodology for the optimization of dispersive liquid\u2013liquid microextraction of chloropropanols in human plasma"],"prefix":"10.1002","volume":"38","author":[{"given":"Paula","family":"Gonzalez\u2010Siso","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Chemistry  University of Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa. A.","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Chemistry  University of Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Regenjo","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, Forensic Toxicology Service Faculty of Medicine  University of Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purificaci\u00f3n","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, Forensic Toxicology Service Faculty of Medicine  University of Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia M.","family":"Carro","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Chemistry  University of Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-009-3177-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.05.024"},{"key":"e_1_2_8_4_1","first-page":"323","volume-title":"Bioactive Compounds in Foods","author":"Hamlet C. G.","year":"2009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2011.08.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.10.055"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-005-3139-y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201100312"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-009-2769-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2007.03.057"},{"key":"e_1_2_8_11_1","first-page":"768","volume":"32","author":"Mezouari S.","year":"2015","journal-title":"Food Addit. Contam. A Chem. Anal. Control Expo. Risk Assess."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652030600887628"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2011.10.058"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2013.809628"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority 2013Analysis of occurrence of 3\u2010monochloropropane\u20101 2\u2010diol (3\u2010MCPD) in food in Europe in the years 2009\u20132011 and preliminary exposure assessment. EFSA Journal 2013 11 3381 45 pp. doi:10.2903\/j.efsa.2013.3381.","DOI":"10.2903\/j.efsa.2013.3381"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-008-0965-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652030701799375"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-011-0657-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.08.074"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-010-0552-6"},{"key":"e_1_2_8_21_1","unstructured":"Tomar R. S. Tsai F. C. Sandy M. S. Reproductive and Cancer Hazard Assessment Branch Office of Environmental Health Hazard Assessment (OEHHA) \u201cEvidence on the carcinogenicity of 3\u2010Monochloropropane\u20101 2\u2010diol (3\u2010MCPD; \u03b1\u2010Chlorohydrin)\u201d pp 33 EPA 2010."},{"key":"e_1_2_8_22_1","unstructured":"Tomar R. S. Tsai F. C. Sandy M. S. Reproductive and Cancer Hazard Assessment Branch Office of Environmental Health Hazard Assessment (OEHHA) \u201cEvidence on the carcinogenicity of 1 3\u2010Dichloro\u20102\u2010Propanol (1 3\u2010DCP; \u03b1 \u03b3\u2010Dichlorohydrin)\u201d pp 38 EPA 2010."},{"key":"e_1_2_8_23_1","first-page":"13","volume-title":"Acid, First Supplement to the 4th ed.","author":"Food Chemical Codex","year":"2003"},{"key":"e_1_2_8_24_1","first-page":"5","article-title":"No. 1881\/2006 19 December 2006 setting maximum levels for certain contaminants in foodstuffs","volume":"364","author":"Commission Regulation (EC)","journal-title":"Off. J. Eur. Union"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2014.07.012"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-3928-9"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.03.007"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.11.088"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-013-7467-z"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-011-0678-0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.03.090"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.050955"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.01.081"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2008.01.039"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-011-4874-x"},{"key":"e_1_2_8_36_1","volume-title":"Pharmaceutical Experimental Design","author":"Lewis G. A.","year":"1999"},{"key":"e_1_2_8_37_1","volume-title":"NEMRODW\u00ae Software versi\u00f3n 2011","author":"Mathieu D."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.04.014"},{"key":"e_1_2_8_39_1","unstructured":"COMMISSION REGULATION (EC) No 333\/2007 of 28 March 2007 laying down the methods of sampling and analysis for the official control of the levels of lead cadmium mercury inorganic tin 3\u2010MCPD and benzo(a)pyrene in foodstuffs Official Journal of the European Union 29.3.2007 L 88\/29."},{"key":"e_1_2_8_40_1","unstructured":"Magnusson B. and\u00d6rnemark U.(Eds.) Eurachem Guide: The Fitness for Purpose of Analytical Methods \u2013 A Laboratory Guide to Method Validation and Related Topics 2ndEdition ISBN 978\u201091\u201087461\u201059\u201002014."},{"key":"e_1_2_8_41_1","volume-title":"DIN EN 14573 Foodstuffs Determination of 3\u2010Monochloropropane\u20101,2\u2010Diol by GC\/MS","year":"2005"},{"key":"e_1_2_8_42_1","unstructured":"Magnusson B. \u00d6rnemark U.(Eds.) Eurachem Guide: The Fitness for Purpose of Analytical Methods \u2013 A Laboratory Guide to Method Validation and Related Topics 2ndEdition ISBN 978\u201091\u201087461\u201059\u201002014."},{"key":"e_1_2_8_43_1","volume-title":"Safety evaluation of certain food additives and contaminants","author":"The Joint FAO\/WHO Expert Committee on Food Additives (JECFA). 3\u2010Chloro\u20101,2\u2010propanediol","year":"2002"},{"key":"e_1_2_8_44_1","unstructured":"The Joint FAO\/WHO Expert Committee on Food Additives (JECFA). Sixty\u2010seventh meeting \u2013 summary and conclusions. Rome. FAO; July 2006."}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.201500468","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.201500468","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.201500468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:53:41Z","timestamp":1760874821000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.201500468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,8]]},"references-count":43,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/jssc.201500468"],"URL":"https:\/\/doi.org\/10.1002\/jssc.201500468","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,8]]}}}