{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:39:57Z","timestamp":1773859197690,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T00:00:00Z","timestamp":1445385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>The classical traditional Chinese formulation LiuweiDihuang, shown to have clinical efficacy for \u201cnourishing kidney\u2010yin\u201d in traditional Chinese medicine, has been used for thousands of years in China. Little attention, however, has been paid to quality control methods for this formulation. Hence, a rapid and sensitive analytical technique is urgently needed for the evaluation of LiuweiDihuang preparations to assess its quality and pharmacological functionality. In this study, an ultra high performance liquid chromatography dual\u2010wavelength method was developed to simultaneously determine 11 constituents in LiuweiDihuang preparations. This robust approach provided a fast and comprehensive quantitative determination of the major bioactive markers within LiuweiDihuang preparations. To distinguish four dosage forms of LiuweiDihuang preparations, a random forest technique was applied on the spectrometric fingerprint data obtained. This combination approach of chromatographic techniques and data analyses might serve as a rapid and efficient tool to ensure the quality of LiuweiDihuang preparations and other Chinese medicinal formulations and can support quality control and scientific research into the pharmacological potential for these formulations.<\/jats:p>","DOI":"10.1002\/jssc.201500560","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T05:07:01Z","timestamp":1440738421000},"page":"3720-3726","source":"Crossref","is-referenced-by-count":24,"title":["Quantitative and qualitative determination of LiuweiDihuang preparations by ultra high performance liquid chromatography in dual\u2010wavelength fingerprinting mode and random forest"],"prefix":"10.1002","volume":"38","author":[{"given":"Yixing","family":"Qiu","sequence":"first","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development Laboratory, Sino\u2010Luxemburg TCM Research Center, School of Pharmacy Hunan University of Chinese Medicine  Changsha P.R. China"},{"name":"Division of Stem Cell Regulation and Application with Chinese Materia Medica Hunan University of Chinese Medicine  Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Huang","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development Laboratory, Sino\u2010Luxemburg TCM Research Center, School of Pharmacy Hunan University of Chinese Medicine  Changsha P.R. China"},{"name":"Research Center of Modernization of Traditional Chinese Medicines Central South University  Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingming","family":"Jiang","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development Laboratory, Sino\u2010Luxemburg TCM Research Center, School of Pharmacy Hunan University of Chinese Medicine  Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development Laboratory, Sino\u2010Luxemburg TCM Research Center, School of Pharmacy Hunan University of Chinese Medicine  Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development Laboratory, Sino\u2010Luxemburg TCM Research Center, School of Pharmacy Hunan University of Chinese Medicine  Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zeng","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development Laboratory, Sino\u2010Luxemburg TCM Research Center, School of Pharmacy Hunan University of Chinese Medicine  Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuzhat","family":"Shehla","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development Laboratory, Sino\u2010Luxemburg TCM Research Center, School of Pharmacy Hunan University of Chinese Medicine  Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development Laboratory, Sino\u2010Luxemburg TCM Research Center, School of Pharmacy Hunan University of Chinese Medicine  Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duanfang","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of Stem Cell Regulation and Application with Chinese Materia Medica Hunan University of Chinese Medicine  Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Guo","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development Laboratory, Sino\u2010Luxemburg TCM Research Center, School of Pharmacy Hunan University of Chinese Medicine  Changsha P.R. China"},{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica Chinese Academy of Science  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizeng","family":"Liang","sequence":"additional","affiliation":[{"name":"Research Center of Modernization of Traditional Chinese Medicines Central South University  Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development Laboratory, Sino\u2010Luxemburg TCM Research Center, School of Pharmacy Hunan University of Chinese Medicine  Changsha P.R. China"},{"name":"Division of Stem Cell Regulation and Application with Chinese Materia Medica Hunan University of Chinese Medicine  Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,21]]},"reference":[{"issue":"6216","key":"e_1_2_8_2_1","first-page":"S13","volume":"346","author":"Wang Y.","journal-title":"Science 2014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/714805"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.59.9.0015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.01.030"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.09.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043990"},{"key":"e_1_2_8_8_1","first-page":"598","volume-title":"Chinese Pharmacopoeia","author":"Pharmacopoeia Commission of the Ministry of Public Health of PRC","year":"2010"},{"key":"e_1_2_8_9_1","first-page":"1261","volume":"48","author":"Xie B.","year":"2008","journal-title":"J. Pharm. Pharmacol. Anal."},{"key":"e_1_2_8_10_1","first-page":"492","volume":"49","author":"Xie B.","year":"2009","journal-title":"J. Pharm. Pharmacol. Anal."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/45.8.549"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.04.025"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2008.12.009"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X12500401"},{"key":"e_1_2_8_15_1","first-page":"223","volume":"4","author":"Yokozawa T.","year":"2010","journal-title":"Drug Discov. Ther"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2003.08.016"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.12.012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.2654"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.05.009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201000905"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201200422"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.201500560","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.201500560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.201500560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:48:32Z","timestamp":1760874512000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.201500560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,21]]},"references-count":20,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/jssc.201500560"],"URL":"https:\/\/doi.org\/10.1002\/jssc.201500560","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,21]]}}}