{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:30:30Z","timestamp":1778585430153,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Key Program of Natural Science Foundation of State","award":["81430093, 81173500, 81373930, 81302905, 81202639"],"award-info":[{"award-number":["81430093, 81173500, 81373930, 81302905, 81202639"]}]},{"name":"National Key Subject of Drug Innovation","award":["2015ZX09101043-005, 2015ZX09101043-011"],"award-info":[{"award-number":["2015ZX09101043-005, 2015ZX09101043-011"]}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province of China","doi-asserted-by":"crossref","award":["H2015038"],"award-info":[{"award-number":["H2015038"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Youth Innovative Talent Program of Heilongjiang Province of China","award":["UNPYSCT-2015118"],"award-info":[{"award-number":["UNPYSCT-2015118"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p><jats:italic>Acanthopanax Senticosus Harms<\/jats:italic>. has been used widely in traditional Chinese medicine for the treatment of chronic bronchitis, neurasthenia, hypertension and ischemic heart disease. However, the in vivo constituents of the stem of <jats:italic>Acanthopanax Senticosus<\/jats:italic> remain unknown. In this paper, ultra high performance liquid chromatography with electrospray ionization quadrupole time\u2010of\u2010flight mass spectrometry and the MarkerLynx<jats:sup>TM<\/jats:sup> software combined with multiple data processing approach were used to study the constituents in vitro and in vivo. The aqueous extract from the <jats:italic>Acanthopanax Senticosus<\/jats:italic> stem and the compositions in rat serum after intragastric administration were completely analyzed. Consequently, 115 compounds in the aqueous extract from <jats:italic>Acanthopanax Senticosus<\/jats:italic> stem and 41 compounds absorbed into blood were characterized. Of the 115 compounds in vitro, 54 were reported for first time, including sinapyl alcohol, sinapyl alcohol diglucoside, and 1\u2010<jats:italic>O<\/jats:italic>\u2010sinapoyl\u2010\u03b2\u2010<jats:sc>d<\/jats:sc>\u2010glucose. In the 41 compounds in vivo, 7 were prototype components and 34 were metabolites which were from 21 components of aqueous extract from <jats:italic>Acanthopanax Senticosus<\/jats:italic> stem, and the metabolic pathways of the metabolites were elucidated for first time. The results narrowed the range of screening the active components and provided a basis for the study of action mechanism and pharmacology.<\/jats:p>","DOI":"10.1002\/jssc.201500915","type":"journal-article","created":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T04:24:38Z","timestamp":1449116678000},"page":"496-502","source":"Crossref","is-referenced-by-count":52,"title":["Characterization of the multiple components of <i>Acanthopanax Senticosus<\/i> stem by ultra high performance liquid chromatography with quadrupole time\u2010of\u2010flight tandem mass spectrometry"],"prefix":"10.1002","volume":"39","author":[{"given":"Hui","family":"Sun","sequence":"first","affiliation":[{"name":"National TCM Key Laboratory of Serum Pharmacochemistry, Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis Heilongjiang University of Chinese Medicine  Harbin 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