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After simple protein precipitation using acetonitrile, the analytes and internal standard diphenhydramine were separated on a Zorbax SB\u2010C<jats:sub>18<\/jats:sub> column (50 \u00d7 4.6 mm, 2.7 \u03bcm) using acetonitrile\/water as the mobile phase at a flow rate of 0.9 mL\/min. The total run time was 6 min for each sample. The validation results of specificity, matrix effects, recovery, linearity, precision, and accuracy were satisfactory. The lower limit of quantification was 0.04 \u03bcg\/mL for carbamazepine, 0.02 \u03bcg\/mL for lamotrigine, 0.01 \u03bcg\/mL for oxcarbazepine, 0.4 \u03bcg\/mL for 10\u2010hydroxycarbazepine, 0.1 \u03bcg\/mL for carbamazepine\u201010,11\u2010epoxide, 0.15 \u03bcg\/mL for levetiracetam, 0.06 \u03bcg\/mL for phenytoin, 0.3 \u03bcg\/mL for valproic acid, 0.03 \u03bcg\/mL for topiramate, and 0.15 \u03bcg\/mL for phenobarbital. The intraday precision and interday precision were less than 7.6%, with the accuracy ranging between \u20138.1 and 7.9%. The method was successfully applied to therapeutic drug monitoring of 1237 patients with epilepsy after administration of standard antiepileptic drugs. The method has been proved to meet the high\u2010throughput requirements in therapeutic drug monitoring.<\/jats:p>","DOI":"10.1002\/jssc.201501067","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T04:42:42Z","timestamp":1451364162000},"page":"964-972","source":"Crossref","is-referenced-by-count":38,"title":["Simultaneous determination of ten antiepileptic drugs in human plasma by liquid chromatography and tandem mass spectrometry with positive\/negative ion\u2010switching electrospray ionization and its application in therapeutic drug monitoring"],"prefix":"10.1002","volume":"39","author":[{"given":"Lei","family":"Yin","sequence":"first","affiliation":[{"name":"School of Life Science Jilin University  Changchun PR China"},{"name":"Clinical Pharmacology Center, Research Institute of Translational Medicine The First Hospital of Jilin University  Changchun PR China"},{"name":"Research Center for Drug Metabolism Jilin University  Changchun PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Science Jilin University  Changchun PR China"},{"name":"Clinical Pharmacology Center, Research Institute of Translational Medicine The First Hospital of Jilin University  Changchun PR China"},{"name":"Research Center for Drug Metabolism Jilin University  Changchun PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiyun","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Life and Medical Sciences Dalian University of Technology  Panjin PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Center, Research Institute of Translational Medicine The First Hospital of Jilin University  Changchun PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Center, Research Institute of Translational Medicine The First Hospital of Jilin University  Changchun PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Life Science Jilin University  Changchun PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingkai","family":"Gu","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Center, Research Institute of Translational Medicine The First Hospital of Jilin University  Changchun PR China"},{"name":"Research Center for Drug Metabolism Jilin University  Changchun PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,28]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Epstein C. 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