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The main factors (the amounts of sample volume, amount of adsorbent, type and amount of extraction organic solvent, time of extraction and desorption, pH, the ionic strength of extraction medium, and agitation rate) influencing the extraction efficiency were investigated and optimized. Under the optimized conditions, good linearity was observed in the range of 100\u20131500\u00a0ng\/mL for amphetamine and 100\u20131000\u00a0ng\/mL for methadone. The method was evaluated for determination of AM and methadone in positive urine samples, satisfactory results were obtained, therefore magnetic solid\u2010phase extraction can be applied as a novel method for the determination of drugs of abuse in forensic laboratories.<\/jats:p>","DOI":"10.1002\/jssc.201600030","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T07:23:40Z","timestamp":1461050620000},"page":"2307-2312","source":"Crossref","is-referenced-by-count":19,"title":["Development and validation of a magnetic solid\u2010phase extraction with high\u2010performance liquid chromatography method for the simultaneous determination of amphetamine and methadone in urine"],"prefix":"10.1002","volume":"39","author":[{"given":"Arezou","family":"Taghvimi","sequence":"first","affiliation":[{"name":"Department of Chemistry, Mashhad branch Islamic Azad University  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Hamishehkar","sequence":"additional","affiliation":[{"name":"Drug Applied Research Center Tabriz University of Medical Science  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mashhad branch Islamic Azad University  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(04)00682-8"},{"key":"e_1_2_8_3_1","volume-title":"Analytical solid\u2010phase extraction, Wiley\u2010VCH, Weinheim","author":"Fritz J. 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