{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:46:19Z","timestamp":1789688779337,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>\n                    An automatic on\u2010line solid\u2010phase extraction with ultra\u2010high performance liquid chromatography and tandem mass spectrometry method was developed for the simultaneous determination of ten antipsychotics in human plasma. The plasma sample after filtration was injected directly into the system without any pretreatment. A Shim\u2010pack MAYI\u2010C\n                    <jats:sub>8<\/jats:sub>\n                    (G) column was used as a solid\u2010phase extraction column, and all the analytes were separated on a Shim\u2010pack XR\u2010ODS III column with a mobile phase consisting of 0.1% v\/v formic acid in water with 5\u00a0mM ammonium acetate and acetonitrile. The method features were systematically investigated, including extraction conditions, desorption conditions, the equilibration solution, the valve switching time, and the dilution for column\u2010head stacking. Under the optimized conditions, the whole analysis procedure took only 10 min. The limits of quantitation were in the range of 0.00321\u20132.75\u00a0\u03bcg\/L and the recoveries ranged from 75.9 to 122%. Compared with the off\u2010line ultra\u2010high performance liquid chromatography and the reported methods, this validated on\u2010line method showed significant advantages such as minimal pretreatment, shortest analysis time, and highest sensitivity. The results indicated that this automatic on\u2010line method was rapid, sensitive, and reliable for the determination of antipsychotics in plasma and could be extended to other target analytes in biological samples.\n                  <\/jats:p>","DOI":"10.1002\/jssc.201600129","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T10:42:35Z","timestamp":1460284955000},"page":"2129-2137","source":"Crossref","is-referenced-by-count":11,"title":["Automatic on\u2010line solid\u2010phase extraction with ultra\u2010high performance liquid chromatography and tandem mass spectrometry for the determination of ten antipsychotics in human plasma"],"prefix":"10.1002","volume":"39","author":[{"given":"Qisheng","family":"Zhong","sequence":"first","affiliation":[{"name":"Shimadzu (China) Corporation  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Shen","sequence":"additional","affiliation":[{"name":"Shimadzu (China) Corporation  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Shimadzu (China) Corporation  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianbao","family":"Yu","sequence":"additional","affiliation":[{"name":"Shimadzu (China) Corporation  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Li","sequence":"additional","affiliation":[{"name":"Shimadzu (China) Corporation  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiru","family":"Li","sequence":"additional","affiliation":[{"name":"Shimadzu (China) Corporation  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinting","family":"Yao","sequence":"additional","affiliation":[{"name":"Shimadzu (China) Corporation  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taohong","family":"Huang","sequence":"additional","affiliation":[{"name":"Shimadzu (China) Corporation  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010ichi","family":"Kawano","sequence":"additional","affiliation":[{"name":"Shimadzu (China) Corporation  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Hashi","sequence":"additional","affiliation":[{"name":"Shimadzu (China) Corporation  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Bioscience and Bioengineering South China University of Technology  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.07.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.12.55"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.143"},{"key":"e_1_2_8_5_1","first-page":"725","article-title":"Application of Ultra High Liquid Chromatography Tandem Mass Spectrometry to the Analysis of Three Atypical Antipsychotics and One Antidepressant: Risperidone, 9\u2010OH Risperidone, Aripiprazole, Dehydro\u2010Aripiprazole, Ziprasidone, Venlafaxine and O\u2010Desmethyl\u2010Venlafaxine (ODES) in Serum and Plasma","volume":"35","author":"Juenke J. 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