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Nitrosodimethylamine precursor identification leads to their control and improved understanding of nitrosodimethylamine formation during chloramination. Mass balances on nitrosodimethylamine precursors were evaluated across solid\u2010phase extraction cartridges and in eluates to select the best combination of solid\u2010phase media and eluent that maximized recovery of nitrosodimethylamine precursors into a solvent amenable to time\u2010of\u2010flight mass spectrometry analysis. After reviewing literature and comparing various solid\u2010phase cartridges and eluent combinations, a method was obtained to efficiently recover nitrosodimethylamine precursors. The approach with the greatest recoveries of nitrosodimethylamine precursors involved cation exchange resin loaded with water samples at pH 3 and eluted with 5% NH<jats:sub>4<\/jats:sub>OH in methanol. This indicated that nitrosodimethylamine precursors are amines that protonate at low pH and deprotonate at high pH. Quaternary amines were irreversibly sorbed to the cation exchange cartridge and did not account for a large fraction of precursors. Overall, a median recovery of 82% for nitrosodimethylamine precursors was achieved from 11 surface waters and one wastewater. Applying this method allowed discovery of methadone as a new nitrosodimethylamine precursor in wastewater effluent and drinking water treatment plant intakes.<\/jats:p>","DOI":"10.1002\/jssc.201600139","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T04:38:34Z","timestamp":1463459914000},"page":"2796-2805","source":"Crossref","is-referenced-by-count":16,"title":["Sorption and desorption of organic matter on solid\u2010phase extraction media to isolate and identify <i>N<\/i>\u2010nitrosodimethylamine precursors"],"prefix":"10.1002","volume":"39","author":[{"given":"David","family":"Hanigan","sequence":"first","affiliation":[{"name":"Department of Civil and Environmental Engineering University of Nevada  Reno NV USA"},{"name":"School of Sustainable Engineering and the Built Environment Arizona State University  Tempe AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Municipal and Environmental Engineering, College of Civil Engineering Huaqiao University  Xiamen Fujian P.R. 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