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It is important to screen and identify the bioactive molecules from its root rapidly. Hereby, an off\u2010line two\u2010dimensional high performance liquid chromatography coupled with diode array detection and tandem time\u2010of\u2010flight mass spectrometry together with 2,2\u02b9\u2010diphenyl\u20101\u2010picrylhydrazyl was established to screen antioxidants from the root of <jats:italic>O. elatus<\/jats:italic>. A Waters cyanogen column (150 \u00d7 3.9 mm, id, 4 \u03bcm) was used for the first dimensional liquid chromatography, while a Hypersil BDS\u2010C18 column (250 \u00d7 4.6 mm, id, 5 \u03bcm) was installed for the second dimension liquid chromatographic analysis. Twenty\u2010eight compounds had been tentatively identified from the methanol extract of the air\u2010dried root of <jats:italic>O. elatus<\/jats:italic> including six polyynes and eight phenolic derivatives were screened with antioxidant activity. The developed method could be expedient for screening and identifying antioxidants from <jats:italic>O. elatus<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/jssc.201600838","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T05:43:02Z","timestamp":1473831782000},"page":"4269-4280","source":"Crossref","is-referenced-by-count":7,"title":["Screening and identifying antioxidants from <i>Oplopanax elatus<\/i> using 2,2\u02b9\u2010diphenyl\u20101\u2010picrylhydrazyl with off\u2010line two\u2010dimensional HPLC coupled with diode array detection and tandem time\u2010of\u2010flight mass spectrometry"],"prefix":"10.1002","volume":"39","author":[{"given":"Li","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Hunan University of Chinese Medicine  Changsha Hunan 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