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High\u2010performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight mass spectrometry was utilized to develop a metabonomic method of the heart homogenates of myocardial infarction rats. Hydrophilic interaction chromatography allows the analysis of high polar metabolites, providing complementary information to reversed\u2010phase liquid chromatography. We combined reversed phase and hydrophilic interaction chromatographic separations to analyze 18 samples, ten from myocardial infarction rat hearts and eight from normal rat hearts. A total of 16 potential biomarkers in rat heart tissue were screened out, primarily related to oxidative stress, nitric oxide damage, taurine, and hypotaurine metabolism and sphingolipid metabolism. This research showed that a comprehensive metabonomic study is a useful tool to reveal the underlying mechanism of myocardial infarction.<\/jats:p>","DOI":"10.1002\/jssc.201601013","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T07:11:02Z","timestamp":1490771462000},"page":"2198-2206","source":"Crossref","is-referenced-by-count":22,"title":["Comprehensive metabonomic analysis of heart tissue from isoproterenol\u2010induced myocardial infarction rat based on reversed\u2010phase and hydrophilic interaction chromatography coupled to mass spectrometry"],"prefix":"10.1002","volume":"40","author":[{"given":"Lei","family":"Sun","sequence":"first","affiliation":[{"name":"Xiyuan hospital China Academy of Chinese Medical Sciences and Beijing key lab of TCM pharmacology  Beijing China"},{"name":"Beijing University of Chinese Medicine  Beijing 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