{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:41:48Z","timestamp":1778751708090,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["KFT\u2010EW\u2010STS\u2010099"],"award-info":[{"award-number":["KFT\u2010EW\u2010STS\u2010099"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21207130, 21477037"],"award-info":[{"award-number":["21207130, 21477037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>An orthogonal two\u2010dimensional solid\u2010phase extraction strategy was established for the selective enrichment of three aminoglycosides including spectinomycin, streptomycin, and dihydrostreptomycin in milk. A reversed\u2010phase liquid chromatography material (C<jats:sub>18<\/jats:sub>) and a weak cation\u2010exchange material (TGA) were integrated in a single solid\u2010phase extraction cartridge. The feasibility of two\u2010dimensional clean\u2010up procedure that experienced two\u2010step adsorption, two\u2010step rinsing, and two\u2010step elution was systematically investigated. Based on the orthogonality of reversed\u2010phase and weak cation\u2010exchange procedures, the two\u2010dimensional solid\u2010phase extraction strategy could minimize the interference from the hydrophobic matrix existing in traditional reversed\u2010phase solid\u2010phase extraction. In addition, high ionic strength in the extracts could be effectively removed before the second dimension of weak cation\u2010exchange solid\u2010phase extraction. Combined with liquid chromatography and tandem mass spectrometry, the optimized procedure was validated according to the European Union Commission directive 2002\/657\/EC. A good performance was achieved in terms of linearity, recovery, precision, decision limit, and detection capability in milk. Finally, the optimized two\u2010dimensional clean\u2010up procedure incorporated with liquid chromatography and tandem mass spectrometry was successfully applied to the rapid monitoring of aminoglycoside residues in milk.<\/jats:p>","DOI":"10.1002\/jssc.201601086","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T08:23:09Z","timestamp":1482135789000},"page":"1099-1106","source":"Crossref","is-referenced-by-count":7,"title":["Two\u2010dimensional solid\u2010phase extraction strategy for the selective enrichment of aminoglycosides in milk"],"prefix":"10.1002","volume":"40","author":[{"given":"Aijin","family":"Shen","sequence":"first","affiliation":[{"name":"Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Pharmacy East China University of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaowa","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingcheng","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy East China University of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimou","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy East China University of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmiao","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Pharmacy East China University of Science and Technology  Shanghai China"},{"name":"Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Chemical Analysis of Antibiotic Residues in Food","author":"Wang J.","year":"2012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201200344"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201400080"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652030802189740"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2008.05.054"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2011.623681"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.03.050"},{"key":"e_1_2_7_9_1","unstructured":"Official Journal of the European Union. 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