{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:28Z","timestamp":1786978168134,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503240"],"award-info":[{"award-number":["81503240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473344"],"award-info":[{"award-number":["81473344"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>\n                    Various traditional Chinese medicine preparations developed from Notoginseng total saponins, including Xueshuantong injection and Xuesaitong injection, are extensively used in China to treat cardiocerebrovascular diseases. However, the difference of their saponin compositions remains unknown. An ultra high performance liquid chromatography with quadrupole time\u2010of\u2010flight mass spectrometry based metabolomics approach was developed to probe the saponin discrimination between Xueshuantong and Xuesaitong and the related factors by large sample analysis. A highly efficient chromatographic separation was achieved on an HSS T3 column within 20 min with the holistic metabolites information recorded in the negative MS\n                    <jats:sup>E<\/jats:sup>\n                    mode. A six\u2010step data pretreatment procedure mainly based on Progenesis QI and mass defect filtering was established. Pattern recognition chemometrics was used to discover the potential saponin markers. The saponin composition of Wuzhou Xueshuantong showed distinct discrimination from the other products. Wuzhou Xueshuantong contains more abundant protopanaxatriol\u2010type noto\u2010R\n                    <jats:sub>1<\/jats:sub>\n                    , Rg\n                    <jats:sub>1<\/jats:sub>\n                    , Re, and protopanaxadiol\u2010type Rb\n                    <jats:sub>1<\/jats:sub>\n                    , but less Rd and other low\u2010polarity protopanaxadiol\u2010type ginsenosides. These differences could not directly correlate to the use of different parts of\n                    <jats:italic>Panax notoginseng<\/jats:italic>\n                    , but possibly to the different preparation techniques employed by different manufacturers. These results are beneficial to the establishment of pharmacopoeia standards and the assessment of the efficacy and adverse drug reactions for these homologous products.\n                  <\/jats:p>","DOI":"10.1002\/jssc.201601122","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T13:45:52Z","timestamp":1481291152000},"page":"834-841","source":"Crossref","is-referenced-by-count":50,"title":["UHPLC\u2013Q\u2010TOF\u2010MS\u2010based metabolomics approach to compare the saponin compositions of Xueshuantong injection and Xuesaitong injection"],"prefix":"10.1002","volume":"40","author":[{"given":"Changliang","family":"Yao","sequence":"first","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangxi Wuzhou Pharmaceutical (Group) Co., Ltd.  Wuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Shi","sequence":"additional","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqin","family":"Pan","sequence":"additional","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Guo","sequence":"additional","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.07.025"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2014.892582"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/134685"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.09.028"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0560-4"},{"key":"e_1_2_7_7_1","first-page":"560","article-title":"Comparison of adverse drug reactions between Xuesaitong Injection and Xueshuantong injection","volume":"231","author":"Ge W. 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