{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:26:24Z","timestamp":1769858784038,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["104\u20102113\u2010M\u2010017\u2010002"],"award-info":[{"award-number":["104\u20102113\u2010M\u2010017\u2010002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>A sensitive method for the determination of mexiletine and lidocaine using surfactant\u2010assisted dispersive liquid\u2013liquid microextraction coupled with capillary electrophoresis was developed. Triton X\u2010100 and dichloromethane were used as the dispersive agent and extraction solvent, respectively. After the extraction, mexiletine and lidocaine were analyzed using capillary electrophoresis with ultraviolet detection. The detection sensitivity was further enhanced through the use of field\u2010amplified sample stacking. Under optimal extraction and stacking conditions, the calibration curves were linear over a concentration range of 0.05\u20131.00\u00a0\u03bcM for mexiletine and 0.03\u20131.00\u00a0\u03bcM for lidocaine. The limits of detection (signal\u2010to\u2010noise ratio\u00a0of\u00a03) were 0.01 and 0.01\u00a0\u03bcM for mexiletine and lidocaine, respectively. An approximately 1141\u2010 to 1250\u2010fold improvement in sensitivity was observed for the two analytes compared with the injection of a standard solution without the surfactant\u2010assisted dispersive liquid\u2013liquid microextraction and field\u2010amplified sample stacking procedures. This developed method was successfully applied to the determination of mexiletine and lidocaine in human urine and serum samples. Both precision and accuracy for urine and serum samples were less than 8.7 and 6.7%, respectively. The recoveries of the two analytes from urine and serum samples were 54.7\u201364.9% and 16.1\u201356.5%, respectively.<\/jats:p>","DOI":"10.1002\/jssc.201700042","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T14:08:15Z","timestamp":1491401295000},"page":"2406-2415","source":"Crossref","is-referenced-by-count":21,"title":["Surfactant\u2010assisted dispersive liquid\u2013liquid microextraction combined with field\u2010amplified sample stacking in capillary electrophoresis for the determination of mexiletine and lidocaine"],"prefix":"10.1002","volume":"40","author":[{"given":"Yu\u2010Hsuan","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Chemistry National Kaohsiung Normal University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Kaohsiung Veterans 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