{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:23:21Z","timestamp":1762917801616,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T00:00:00Z","timestamp":1503878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydrophilic interaction liquid chromatography on bare silica presents some benefits for analysis and purification of ionizable basic alkaloids. This mode was used to separate five major opium alkaloids: morphine, codeine, thebaine, papaverine, and noscapine. Central composite design based on response surface methodology was applied for experimental design, modeling, and optimization in a single\u2010step gradient method. The main effects and their interactions (initial percentage of modifier, changing range of modifier in run time, pH of buffer, and its concentration) were investigated in 30 experiments. Multivariate curve resolution\u2010alternating least squares, by resolving overlapped curves, helped in the accurate calculation of baseline resolution factors to be modeled and optimized more accurately. Then three crucial resolution factors besides elution time were modeled in quadratic and cubic equations and optimized. In addition to the four factors, five extra logarithmic, and nonlogarithmic factors extracted from the four factors to give nine factors overall were inspected on mechanism of retention. It was shown that a linear combination consist of four independence variables successfully describes morphinans retentivity in a single\u2010step gradient method.<\/jats:p>","DOI":"10.1002\/jssc.201700416","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T04:22:39Z","timestamp":1500265359000},"page":"3602-3611","source":"Crossref","is-referenced-by-count":13,"title":["Response surface methodology based on central composite design accompanied by multivariate curve resolution to model gradient hydrophilic interaction liquid chromatography: Prediction of separation for five major opium alkaloids"],"prefix":"10.1002","volume":"40","author":[{"given":"Mohammadreza","family":"Taheri","sequence":"first","affiliation":[{"name":"Medicinal Plants and Drugs Research Institute Shahid Beheshti University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Medicinal Plants and Drugs Research Institute Shahid Beheshti University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roudabeh Sadat","family":"Moazeni\u2010Pourasil","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemistry Kharazmi University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7940-5884","authenticated-orcid":false,"given":"Alireza","family":"Ghassempour","sequence":"additional","affiliation":[{"name":"Medicinal Plants and Drugs Research Institute Shahid Beheshti University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200900537"},{"key":"e_1_2_7_3_1","first-page":"304","article-title":"Computer assisted optimization of reversed\u2010phase HPLC isocratic separations of neutral compounds","volume":"14","author":"Baczek T.","year":"2001","journal-title":"LC\u2010GC Europe"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(03)00206-1"},{"volume-title":"Chemometrics: Experimental Design","year":"1991","author":"Morgan E.","key":"e_1_2_7_5_1"},{"volume-title":"Design and Analysis of Experiments","year":"2001","author":"Montgomery D. 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