{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:52:39Z","timestamp":1761490359435,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"key Research Project","award":["ZDYF2016174"],"award-info":[{"award-number":["ZDYF2016174"]}]},{"name":"Creative Research Groups of Natural Science Foundation","award":["2017CXTD022"],"award-info":[{"award-number":["2017CXTD022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Morinda officinalis<\/jats:italic> (Rubiaceae) is a traditional Chinese medicine widely used for the treatment of impotence and osteoporosis in clinical therapy. In the present study, a rapid and simple ultra\u2010high performance liquid chromatography with photodiode array detection method was developed and validated for the simultaneous determination of 11 bioactive compounds in <jats:italic>M. officinalis<\/jats:italic>. This assay method was validated with respect to linearity (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup><jats:italic><jats:sup>\u00a0<\/jats:sup><\/jats:italic>&gt;\u00a00.9991), precision, repeatability, limit of detection, limit of quantification, and accuracy (with observed recovery rates between 94.21 and 100.38%). The quantitative results revealed significant differences in the concentrations of the selected compounds. Additionally, chemometric methods, including hierarchical clustering analysis, principal component analysis, and partial least\u2010squares discriminate analysis, were applied to compare and sort the 25 batches of <jats:italic>M. officinalis<\/jats:italic> samples based on the quantitative data of the analytes. All of the samples were clearly divided into two groups: the Hainan samples were successfully discriminated from the samples from other origins. Simultaneous determination of multiple compounds using the proposed method combined with chemometrics could be a viable strategy to compare and evaluate the quality of <jats:italic>M. officinalis<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/jssc.201700484","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T10:22:44Z","timestamp":1502965364000},"page":"3996-4003","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation and quantitative analysis of 11 compounds in <i>Morinda officinalis<\/i> using ultra\u2010high performance liquid chromatography and photodiode array detection coupled with chemometrics"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9943-7218","authenticated-orcid":false,"given":"Xiangsheng","family":"Zhao","sequence":"first","affiliation":[{"name":"Hainan Branch Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College  Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-7467","authenticated-orcid":false,"given":"Weijun","family":"Kong","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hainan Branch Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College  Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhe","family":"Wei","sequence":"additional","affiliation":[{"name":"Hainan Branch Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College  Haikou China"},{"name":"Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihua","family":"Yang","sequence":"additional","affiliation":[{"name":"Hainan Branch Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College  Haikou China"},{"name":"Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.08.013"},{"volume-title":"Pharmacopoeia of People's Republic of China","year":"2015","author":"Chinese Pharmacopoeia Commission","key":"e_1_2_7_3_1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14010573"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.08.013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3532"},{"key":"e_1_2_7_7_1","first-page":"1187","article-title":"Determination of main iridoid glycosides from Morindae officinalis radix of different producting areas by HPLC","volume":"34","author":"Wang Y.","year":"2011","journal-title":"Chin. 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