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The synthesized sorbent was characterized by several spectroscopic techniques. The maximum extraction efficiency for extraction of 500\u00a0\u03bcg\/L antidepressant drugs from aqueous solution was obtained with 15\u00a0mg of magnetite\u2010MCM\u201041 at pH 12. The analyte was desorbed using 100\u00a0\u03bcL of acetonitrile prior to gas chromatography determination. This method was rapid in which the adsorption procedure was completed in 60\u00a0s. Under the optimized conditions using 15\u00a0mL of antidepressant drugs sample, the calibration curve showed good linearity in the range of 0.05\u2013500\u00a0\u03bcg\/L (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.996\u20130.999). Good limits of detection (0.008\u20130.010 \u03bcg\/L) were obtained for the analytes with good relative standard deviations of\u00a0&lt;8.0% (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) for the determination of 0.1, 5.0, and 500.0\u00a0\u03bcg\/L of antidepressant drugs. This method was successfully applied to the determination of amitriptyline and chlorpromazine in plasma and urine samples. The recoveries of spiked plasma and urine samples were in the range of 86.1\u2013115.4%. Results indicate that magnetite micro\u2010solid\u2010phase extraction with gas chromatography and mass spectrometry is a convenient, fast, and economical method for the extraction and determination of amitriptyline and chlorpromazine in biological samples.<\/jats:p>","DOI":"10.1002\/jssc.201700549","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T10:56:46Z","timestamp":1503572206000},"page":"4222-4233","source":"Crossref","is-referenced-by-count":24,"title":["Magnetic micro\u2010solid\u2010phase extraction based on magnetite\u2010MCM\u201041 with gas chromatography\u2013mass spectrometry for the determination of antidepressant drugs in biological fluids"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6299-8767","authenticated-orcid":false,"given":"Sazlinda","family":"Kamaruzaman","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Science Universiti Putra Malaysia  Serdang Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Marsin","family":"Sanagi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Universiti Teknologi Malaysia  Johor Bahru Johor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noorfatimah","family":"Yahaya","sequence":"additional","affiliation":[{"name":"Integrative Medicine Cluster Advanced Medical and Dental Institute (AMDI) Universiti Sains Malaysia  Kepala Batas Penang Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0991-770X","authenticated-orcid":false,"given":"Wan Aini","family":"Wan Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Universiti Teknologi Malaysia  Johor Bahru Johor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salasiah","family":"Endud","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Universiti Teknologi Malaysia  Johor Bahru Johor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Nazihah","family":"Wan Ibrahim","sequence":"additional","affiliation":[{"name":"Faculty of Applied Sciences Universiti Teknologi MARA  Shah Alam Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Nano Chromatography and Capillary Electrophoresis: Pharmaceutical and Environmental Analyses","author":"Imran A.","year":"2009"},{"key":"e_1_2_7_3_1","volume-title":"Instrumental Methods in Metal Ions Speciation: Chromatography, Capillary Electrophoresis and Electrochemistry","author":"Imran A.","year":"2006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200800123"},{"key":"e_1_2_7_5_1","first-page":"22","article-title":"Superficially porous and monolithic columns: Tools for ultra\u2010fast separations in HPLC","volume":"27","author":"Imran A.","year":"2009","journal-title":"LC\u2013GC"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2016.11.062"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.10.033"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201700274"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(98)00338-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.09.060"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sab.2007.12.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie000695c"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2012.10.040"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2017.03.020"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.02.035"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.11.035"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie0010666"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijhydene.2016.03.050"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2015.09.069"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-2991(04)80845-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2005.04.018"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.09.017"},{"key":"e_1_2_7_23_1","first-page":"3375","article-title":"Solid\u2010phase membrane tip extraction combined with liquid chromatography for the determination of azole antifungal drugs in human plasma","volume":"6","author":"Noorfatimah Y.","year":"2013","journal-title":"Anal. 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