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In this work, a high\u2010performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight mass spectrometry method was first established for the separation and structural identification of the chemical constituents in Ardisiae Japonicae Herba. A total of 15 compounds including coumarins, flavonoid glycosides, and catechins were identified or tentatively characterized based on their chromatographic behaviors and mass spectral fragmentation and by comparisons with the reference standards. Furthermore, a simple high\u2010performance liquid chromatography with diode array detection method was developed for the simultaneous determination of five major constituents. Results obtained from method validation, including linearity, precision, repeatability, stability, and recovery, showed that the established method was reliable and accurate. Bergenin and quercitrin were found to be the most abundant constituents and could be served as chemical markers for quality control of Ardisiae Japonicae Herba.<\/jats:p>","DOI":"10.1002\/jssc.201700667","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T10:24:17Z","timestamp":1505816657000},"page":"4347-4356","source":"Crossref","is-referenced-by-count":21,"title":["Qualitative and quantitative analysis of chemical constituents in Ardisiae Japonicae Herba"],"prefix":"10.1002","volume":"40","author":[{"given":"Ke\u2010Yun","family":"Yu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Gao","sequence":"additional","affiliation":[{"name":"Shineway Pharmaceutical Group Co. Ltd.  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang\u2010Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Li","family":"Dou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Zhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plants Yunnan Academy of Agricultural Sciences  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7281-210X","authenticated-orcid":false,"given":"E\u2010Hu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.09.037"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/np960074h"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/np060359m"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0604681"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.08.027"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020310001596033"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1283495"},{"key":"e_1_2_7_9_1","first-page":"361","volume-title":"Pharmacopoeia of the People's Republic of China 2015","author":"Chinese Pharmacopoeia Commission","year":"2015"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201100736"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201100254"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.03.038"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf052137k"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2015.09.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.03.008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.08.020"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-0079-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.03.025"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)01568-0"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.201700667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.201700667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:16:01Z","timestamp":1760872561000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.201700667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,11]]},"references-count":18,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/jssc.201700667"],"URL":"https:\/\/doi.org\/10.1002\/jssc.201700667","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,11]]}}}