{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:19:49Z","timestamp":1770974389256,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A modified dispersive liquid phase microextraction based on sequential injection solidified floating organic drop was developed for simultaneous separation\/preconcentration of trace amounts of phenobarbital and phenytoin. The important factors affecting on the extraction recovery including pH, the volume of extraction solvent, ionic strength, and the number of injections were investigated and optimized by Box\u2013Behnken design and desirability function. Under the optimum experimental conditions, the calibration graph was linear in the concentration range of 1.0\u2013300.0\u00a0\u03bcg\/L (<jats:italic>r<\/jats:italic><jats:sup>2\u00a0<\/jats:sup>=\u00a00.997) for phenobarbital and 2.0\u2013400.0\u00a0\u03bcg\/L (<jats:italic>r<\/jats:italic><jats:sup>2\u00a0<\/jats:sup>=\u00a00.996) for phenytoin. The limit of detection and limit of quantification were 0.35 and 1.2\u00a0\u03bcg\/L for phenobarbital and 0.65 and 2.2\u00a0\u03bcg\/L for phenytoin, respectively. The relative standard deviation for six replicate determinations at 10\u00a0\u03bcg\/L was 3.3 and 4.1% for phenobarbital and phenytoin, respectively. The developed method was successfully applied to the determination of phenobarbital and phenytoin in urine and plasma samples.<\/jats:p>","DOI":"10.1002\/jssc.201701111","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T02:12:40Z","timestamp":1510539160000},"page":"509-517","source":"Crossref","is-referenced-by-count":28,"title":["Modified dispersive liquid\u2010phase microextraction based on sequential injection solidified floating organic drop combined with HPLC for the determination of phenobarbital and phenytoin"],"prefix":"10.1002","volume":"41","author":[{"given":"Arezou","family":"Amiri Pebdani","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Yazd University  Yazd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6191-0775","authenticated-orcid":false,"given":"Shayessteh","family":"Dadfarnia","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Yazd University  Yazd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1494-8949","authenticated-orcid":false,"given":"Ali Mohammad","family":"Haji Shabani","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Yazd University  Yazd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeid","family":"Khodadoust","sequence":"additional","affiliation":[{"name":"Department of Chemistry Behbahan Khatam Alanbia University of Technology  Behbahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Sharif","family":"Talebianpoor","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center Yasuj University of Medical Science  Yasuj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2015.05.005"},{"key":"e_1_2_6_3_1","first-page":"419","article-title":"Salting\u2010out assisted liquid\/liquid extraction with acetonitrile: a new high throughput sample preparation technique for good laboratory practice bioanalysis using liquid chromatography\u2013mass spectrometry","volume":"23","author":"Zhang J.","year":"2009","journal-title":"J. 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