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A two\u2010phase solvent system composed of chloroform containing 0.10\u00a0mol\/L of di\u2010<jats:italic>n<\/jats:italic>\u2010hexyl <jats:sc>l\u2010<\/jats:sc>tartrate\/0.10\u00a0mol\/L of boric acid aqueous solution (1:1, v\/v) was selected, in which 20\u00a0mmol\/L triethylamine was added in the organic phase as a retainer and 2\u00a0mmol\/L HCl was added in the aqueous phase as an eluter. Fifty milligrams of each racemate was completely enantioseparated by pH\u2010zone\u2010refining countercurrent chromatography to yield each enantiomer with a purity of more than 98%, and the recovery of each separated enantiomer reached around 76\u201382%.<\/jats:p>","DOI":"10.1002\/jssc.201701181","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:22:46Z","timestamp":1511742166000},"page":"1433-1441","source":"Crossref","is-referenced-by-count":7,"title":["Application of pH\u2010zone\u2010refining countercurrent chromatography in the chiral separation of two \u03b2\u2010adrenergic blocking agents"],"prefix":"10.1002","volume":"41","author":[{"given":"Liqiong","family":"Lv","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhisi","family":"Bu","sequence":"additional","affiliation":[{"name":"College of 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