{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:28:18Z","timestamp":1768289298267,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["16\u201017689Y)"],"award-info":[{"award-number":["16\u201017689Y)"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008269","name":"Michigan Institute for Clinical and Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the enantiomeric separation of highly polar compounds, a traditionally challenging task for high\u2010performance liquid chromatography, ion\u2010exchange chiral stationary phases have found the main field of application. In this contribution, we present a series of novel anion\u2010exchange\u2010type chiral stationary phases for enantiomer separation of protected amino phosphonates and N\u2010protected amino acids. Two of the prepared selectors possessed a double and triple bond within a single molecule. Thus, they were immobilized onto silica support employing either a thiol\u2010ene (radical) or an azide\u2010yne (copper(I)\u2010catalyzed) click reaction. We evaluated the selectivity and the effect of immobilization proceeding either by the double bond of the <jats:italic>Cinchona<\/jats:italic> alkaloid or a triple bond of the carbamoyl moiety on the chromatographic performance of the chiral stationary phases using analytes with protecting groups of different size, flexibility, and \u03c0\u2010acidity. The previously observed preference toward protecting groups possessing \u03c0\u2010acidic units, which is a typical feature of <jats:italic>Cinchona<\/jats:italic>\u2010based chiral stationary phases, was preserved. In addition, increasing the bulkiness of the selectors\u2019 carbamoyl units leads to significantly reduced retention times, while very high selectivity toward the tested analytes is retained.<\/jats:p>","DOI":"10.1002\/jssc.201701213","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:26:58Z","timestamp":1516793218000},"page":"1355-1364","source":"Crossref","is-referenced-by-count":23,"title":["Effect of different immobilization strategies on chiral recognition properties of <i>Cinchona<\/i>\u2010based anion exchangers"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1447-4453","authenticated-orcid":false,"given":"Michal","family":"Kohout","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry University of Chemistry and Technology Prague  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Wernisch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\u2010Nephrology University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159\u00ed","family":"T\u016fma","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry University of Chemistry and Technology Prague  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Hettegger","sequence":"additional","affiliation":[{"name":"Division of Chemistry of Renewable Resources Department of Chemistry University of Natural Resources and Life Sciences  Tulln Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"P\u00edcha","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry The Academy of Sciences of the Czech Republic  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.10.022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-014-7930-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.10.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1365\/s10337-003-0097-4","article-title":"Evaluation of different surface\u2010anchoring strategies for Cinchona carbamate type selectors","volume":"58","author":"Krawinkler K. 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