{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:08:43Z","timestamp":1791558523225,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The performances of core\u2013shell 2.7\u00a0\u03bcm and fully porous sub\u20102\u00a0\u03bcm particles packed in narrow diameter columns were compared under the same chromatographic conditions. The stationary phases were compared for fast separation and determination of five new antiviral drugs; daclatasvir, sofosbuvir, velpatasvir, simeprevir, and ledipasvir. The gradient elution was done using ethanol as green organic modifier, which is more environmentally friendly. Although both columns provided very good resolution of the five drugs, core\u2013shell particles had proven to be of better efficiency. Under gradient elution conditions, core\u2013shell particles exhibited faster elution, better peak shape, and enhanced resolution adding to lower system backpressure. The column backpressure on sub\u20102\u00a0\u03bcm particles was more than twice that on core\u2013shell particles. This gives a chance to use conventional high\u2010performance liquid chromatography conditions without needing special instrumentation as that required for ultra\u2010high performance liquid chromatography. The method was validated for determination of the five drugs by gradient elution using mobile phase composed of organic modifier ethanol and aqueous part containing 0.75\u00a0g sodium octane sufonate and 3.0\u00a0g sodium dihydrogen phosphate per liter at pH of 6.15. Detection was done using UV\u2010detector set at 210\u00a0nm. The linearity, accuracy, and precision were found very good within the concentration range of 2\u2013200\u00a0\u03bcg\/mL.<\/jats:p>","DOI":"10.1002\/jssc.201701263","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T07:00:45Z","timestamp":1514962845000},"page":"1734-1742","source":"Crossref","is-referenced-by-count":19,"title":["Comparison between core\u2013shell and totally porous particle stationary phases for fast and green LC determination of five hepatitis\u2010C antiviral drugs"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7421-1220","authenticated-orcid":false,"given":"Adel Ehab","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Egyptian International Pharmaceutical Industries Co. \u201cEIPICo.\u201d  10th of Ramadan City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham","family":"Hashem","sequence":"additional","affiliation":[{"name":"Pharmaceutical analytical chemistry department Faculty of Pharmacy Zagazig University  Zagazig Egypt"},{"name":"Chemistry department Faculty of Science Jazan University  Jizan Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Elhenawee","sequence":"additional","affiliation":[{"name":"Pharmaceutical analytical chemistry department Faculty of Pharmacy Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa","family":"Saleh","sequence":"additional","affiliation":[{"name":"Pharmaceutical analytical chemistry department Faculty of Pharmacy Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"24","article-title":"Ultra\u2010performance liquid chromatography: an introduction and review","volume":"2","author":"Reddy T.","year":"2012","journal-title":"IJPRA"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac053516f"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac961094r"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2005.06.035"},{"key":"e_1_2_7_6_1","first-page":"1056","article-title":"UPLC\u2010A review","volume":"2","author":"Taleuzzaman M.","year":"2015","journal-title":"Austin J. 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