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Mixed\u2010mode chromatography has been used in such cases because it combines two or more modes of separation. Charged aerosol detector is also an alternative since its detection is independent of optical properties and analyte ionization. This study is aimed to develop and validate two new stability\u2010indicating methods by high\u2010performance liquid chromatography for the main degradation products of topiramate using mixed\u2010mode chromatography and a charged aerosol detector. Method 1 employed an Acclaim Trinity P1\u00ae column (3.0\u00a0mm\u00a0\u00d7\u00a0150\u00a0mm, 2.7\u00a0\u03bcm) with a mobile phase comprising of 80% ammonium acetate buffer (20\u00a0mM, pH 4.0) and 20% methanol at a flow rate of 0.5\u00a0mL\/min at 35\u00b0C. Method 2 utilized a C18 Acclaim 120\u00ae column (4.6\u00a0mm\u00a0\u00d7\u00a0250\u00a0mm; 5\u00a0\u03bcm) with ACN\/water (50:50) at a flow rate of 0.6\u00a0mL\/min at 50\u00b0C. Validation of the two methods demonstrated excellent performance with respect to linearity, precision, accuracy, and selectivity. The limits of detection for topiramate, fructose, sulfate, sulfamate, and compound A were 2.97, 12.08, 4.02, 13.91, and 3.94\u00a0\u03bcg\/mL, respectively.<\/jats:p>","DOI":"10.1002\/jssc.201701340","type":"journal-article","created":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T01:22:37Z","timestamp":1514596957000},"page":"1716-1725","source":"Crossref","is-referenced-by-count":14,"title":["Development and validation of a stability\u2010indicating HPLC method for topiramate using a mixed\u2010mode column and charged aerosol detector"],"prefix":"10.1002","volume":"41","author":[{"given":"Eduardo Costa","family":"Pinto","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics Faculty of Pharmacy Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"},{"name":"Department of Chemistry and Biochemistry University of Texas at Arlington  Arlington TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana da Silva","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Faculty of Pharmacy Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio Mendes","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Faculty of Pharmacy Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Texas at Arlington  Arlington TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria Pereira","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Faculty of Pharmacy Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2008.00041.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm900141j"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802609789630938"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.03.033"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2014.07.015"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2014.876008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3466"},{"key":"e_1_2_7_9_1","first-page":"280","article-title":"Topiramate: a review of analytical approaches for the drug substance, its impurities and pharmaceutical formulations","volume":"54","author":"Pinto E.","year":"2016","journal-title":"J. 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