{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:48:42Z","timestamp":1790473722638,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"crossref","award":["16-05942S)"],"award-info":[{"award-number":["16-05942S)"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A cellulose tris\u2010(3,5\u2010dimethylphenylcarbamate)\u2010based chiral stationary phase was studied as a tool for the enantioselective separation of 21 selected analytes with different pharmaceutical and physicochemical properties. The enantioseparations were performed using supercritical fluid chromatography. The effect of the mobile phase composition was studied. Four different additives (diethylamine, triethylamine, isopropylamine, and trifluoroacetic acid) and isopropylamine combined with trifluoroacetic acid were tested and their influence on enantioseparation was compared. The influence of two different mobile phase co\u2010solvents (methanol and propan\u20102\u2010ol) combined with all the additives was also evaluated. The best mobile phase compositions for the separation of the majority of enantiomers were CO<jats:sub>2<\/jats:sub>\/methanol\/isopropylamine 80:20:0.1 v\/v\/v or CO<jats:sub>2<\/jats:sub>\/propan\u20102\u2010ol\/isopropylamine\/trifluoroacetic acid 80:20:0.05:0.05 v\/v\/v\/v. The best results were obtained from the group of basic \u03b2\u2010blockers. A high\u2010performance liquid chromatography separation system composed of the same stationary phase and mobile phase of similar properties prepared as a mixture of hexane\/propan\u20102\u2010ol\/additive 80:20:0.1 v\/v\/v was considered for comparison. Supercritical fluid chromatography was found to yield better results, i.e. better enantioresolution for shorter analysis times than high\u2010performance liquid chromatography. However, examples of enantiomers better resolved under the optimized conditions in high\u2010performance liquid chromatography were also found.<\/jats:p>","DOI":"10.1002\/jssc.201701341","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T11:31:20Z","timestamp":1514892680000},"page":"1471-1478","source":"Crossref","is-referenced-by-count":41,"title":["Cellulose tris\u2010(3,5\u2010dimethylphenylcarbamate)\u2010based chiral stationary phase for the enantioseparation of drugs in supercritical fluid chromatography: comparison with HPLC"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4988-8322","authenticated-orcid":false,"given":"Kv\u011bta","family":"Kal\u00edkov\u00e1","sequence":"first","affiliation":[{"name":"Department of Physical and Macromolecular Chemistry, Faculty of Science Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Mart\u00ednkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Physical and Macromolecular Chemistry, Faculty of Science Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0055-660X","authenticated-orcid":false,"given":"Martin G.","family":"Schmid","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences Department of Pharmaceutical Chemistry University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Tesa\u0159ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Physical and Macromolecular Chemistry, Faculty of Science Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2017.08.022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201500270"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201600820"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2014.02.036"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.12.083"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(03)00725-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2017.07.021"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201501062"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.22701"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.10.033"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201000249"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.06.084"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2016.04.044"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201401002"},{"key":"e_1_2_7_16_1","article-title":"Enantioseparation of nornicotine in tobacco by Ultraperformance Convergence Chromatography with Tandem Mass Spectrometry","author":"Deng H.","journal-title":"J. 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