{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:19:24Z","timestamp":1760919564350,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21505030","21575033"],"award-info":[{"award-number":["21505030","21575033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["B2015201024"],"award-info":[{"award-number":["B2015201024"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An ionic\u2010liquid\u2010based polymer monolithic column was synthesized by free radical polymerization within the confines of a stainless\u2010steel column (50\u00a0mm\u00a0\u00d7\u00a04.6\u00a0mm id). In the processes, ionic liquid and stearyl methacrylate were used as dual monomers, ethylene glycol dimethacrylate as the cross\u2010linking agent, and polyethylene glycol 200 and isopropanol as co\u2010porogens. Effects of the prepolymerization solution components on the properties of the resulting monoliths were studied in detail. Scanning electron microscopy, nitrogen adsorption\u2013desorption measurements, and mercury intrusion porosimetry were used to investigate the morphology and pore size distribution of the prepared monoliths, which showed that the homemade ionic\u2010liquid\u2010based monolith column possessed a relatively uniform macropore structure with a total macropore specific surface area of 44.72\u00a0m<jats:sup>2<\/jats:sup>\/g. Compared to a non\u2010ionic\u2010liquid\u2010based monolith prepared under the same conditions, the ionic\u2010liquid\u2010based monolith exhibited excellent selectivity and high performance for separating proteins from complex biosamples, such as egg white, snailase, bovine serum albumin digest solution, human plasma, etc., indicating promising applications in the fractionation and analysis of proteins from the complex biosamples in proteomics research.<\/jats:p>","DOI":"10.1002\/jssc.201701369","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T23:53:03Z","timestamp":1516837983000},"page":"1923-1929","source":"Crossref","is-referenced-by-count":5,"title":["Fabrication of an ionic\u2010liquid\u2010based polymer monolithic column and its application in the fractionation of proteins from complex biosamples"],"prefix":"10.1002","volume":"41","author":[{"given":"Doudou","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences Hebei University  Baoding P. 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