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On basis of the optimized freeze\u2013thaw approach, a convenient, selective, and reproducible liquid chromatography with tandem mass spectrometry method was developed. At three spiking levels in blank chicken and medicated chicken muscles, average recoveries of the analytes were in the range of 71\u2013106 and 63\u2013119%, respectively. All the relative standard deviations were &lt;20%. The limits of quantification of analytes were 0.2\u20135.0\u00a0ng\/g. Regardless of the chicken levels, there were no significant differences (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) in the average contents of almost any of the analytes in medicated chickens between this method and specific methods in the literature for the determination of specific analytes. Finally, the developed method was successfully extended to the monitoring of residues of 55 common veterinary drugs in food animal muscles.<\/jats:p>","DOI":"10.1002\/jssc.201701510","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T21:19:26Z","timestamp":1521839966000},"page":"2461-2472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Freeze\u2013thaw approach: A practical sample preparation strategy for residue analysis of multi\u2010class veterinary drugs in chicken muscle"],"prefix":"10.1002","volume":"41","author":[{"given":"Meiyu","family":"Zhang","sequence":"first","affiliation":[{"name":"National Reference Laboratory of Veterinary Drug Residues (SCAU) College of Veterinary Medicine South China Agricultural University  Guangzhou Guangdong P. R. 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