{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:34:27Z","timestamp":1790393667719,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["1.1.1.1\/16\/A\/258"],"award-info":[{"award-number":["1.1.1.1\/16\/A\/258"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An analytical method based on liquid chromatography with quadrupole time\u2010of\u2010flight mass spectrometry has been developed for the simultaneous determination of six aminoglycoside antibiotics in honey. The sample pretreatment included extraction with aqueous trichloroacetic acid followed by solid\u2010phase extraction on Strata\u2010X polymeric reversed phase cartridges. Liquid chromatography separation was performed on an Obelisc R zwitterionic type mixed\u2010mode column. An ionBooster\u2122 heated electrospray source was used and showed enhanced ionization efficiency in comparison to a conventional electrospray source. The observed signal enhancement ranged from 3\u2010 (neomycin) to 16\u2010fold (gentamicin C1). A data\u2010dependent mass spectrometry acquisition approach was employed, in which the full mass spectrometry dataset provided quantification and a scheduled precursor list was used to trigger an alternating data\u2010dependent acquisition of MS<jats:sup>2<\/jats:sup> spectra for confirmation purposes. The described method was validated in accordance to CD 2002\/657\/EC. Decision limit values were in the range 11.2\u201333.6\u00a0ng\/g, and satisfactory performance characteristics were obtained for recovery (65\u201376%), repeatability (3.8\u20137.3%), and linearity (\u22650.995). The method was applied to the analysis of 49 real honey samples from the country of Georgia. Streptomycin was detected in two samples at 117 and 35\u00a0ng\/g, and gentamicin C1 was detected in one sample at 32\u00a0ng\/g.<\/jats:p>","DOI":"10.1002\/jssc.201800230","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T17:06:27Z","timestamp":1529514387000},"page":"3186-3194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Simultaneous screening and quantification of aminoglycoside antibiotics in honey using mixed\u2010mode liquid chromatography with quadrupole time\u2010of\u2010flight mass spectroscopy with heated electrospray ionization"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4773-5667","authenticated-orcid":false,"given":"Ingus","family":"Perkons","sequence":"first","affiliation":[{"name":"Institute of Food Safety Animal Health and Environment \"BIOR\"  Riga Latvia"},{"name":"Department of Chemistry University of Latvia  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iveta","family":"Pugajeva","sequence":"additional","affiliation":[{"name":"Institute of Food Safety Animal Health and Environment \"BIOR\"  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6193-7409","authenticated-orcid":false,"given":"Vadims","family":"Bartkevics","sequence":"additional","affiliation":[{"name":"Institute of Food Safety Animal Health and Environment \"BIOR\"  Riga Latvia"},{"name":"Department of Chemistry University of Latvia  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.09.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0025-6196(11)65134-3","article-title":"The Aminoglycosides","volume":"74","author":"Randall S. 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