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Chloroform and acetonitrile were selected as the extraction and dispersive solvents, and based on the extraction efficiency, their optimum volumes were 200 and 100\u00a0\u03bcL, respectively. The optimum volumes of the derivatizing agent (isobutyl chloroformate) and catalyst (pyridine), pH, and concentration of NaCl in the sample solution were determined to be 25 and 100\u00a0\u03bcL, pH\u00a07.6, and 0%\u00a0w\/v, respectively. Validation of the optimized method showed good linearity (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0&gt;\u00a00.999), accuracy (\u226589.86%), intra\u2010 (\u22646.70%) and interday (\u22644.17%) repeatability, limit of detection (0.96\u00a0\u03bcg\/L), and limit of quantification (5.79\u00a0\u03bcg\/L). The validated method was applied to quantify 4\u2010methylimidazole in red ginseng juices and concentrates, 4\u2010methylimidazole was only found in red ginseng juices containing caramel colorant (42.91\u20132863.4\u00a0\u03bcg\/L) and detected in red ginseng concentrates containing &gt;1% caramel colorant.<\/jats:p>","DOI":"10.1002\/jssc.201800559","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T05:42:45Z","timestamp":1531978965000},"page":"3415-3423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Dispersive liquid\u2013liquid microextraction with in situ derivatization coupled with gas chromatography and mass spectrometry for the determination of 4\u2010methylimidazole in red ginseng products containing caramel colors"],"prefix":"10.1002","volume":"41","author":[{"given":"Jangho","family":"Lee","sequence":"first","affiliation":[{"name":"245, Nongsaengmyeong\u2010ro Korea Food Research Institute  Wanju\u2010gun Jeollabuk\u2010do Republic of Korea"},{"name":"Department of Food Biotechnology, 217, Gajeong\u2010ro Korea University of Science and Technology  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyeol","family":"Lee","sequence":"additional","affiliation":[{"name":"245, Nongsaengmyeong\u2010ro Korea Food Research Institute  Wanju\u2010gun Jeollabuk\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Gyu","family":"Nam","sequence":"additional","affiliation":[{"name":"245, Nongsaengmyeong\u2010ro Korea Food Research Institute  Wanju\u2010gun Jeollabuk\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4797-9880","authenticated-orcid":false,"given":"Hae Won","family":"Jang","sequence":"additional","affiliation":[{"name":"245, Nongsaengmyeong\u2010ro Korea Food Research Institute  Wanju\u2010gun 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