{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:07:53Z","timestamp":1790838473370,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>10\u2010Hydroxycamptothecin is a drug to cure various cancers. However, the 10\u2010hydroxycamptothecin cannot be widely applied in clinics due to fast elimination and resistance of various cancers to the drug. Nevertheless, co\u2010treatment with tetrandine is known to reverse the resistance of multi\u2010drug resistant cancers, and may present an effective strategy to improve the efficacy of 10\u2010hydroxycamptothecin. In order to improve the bioavailability and prolong the treatment time of the 10\u2010hydroxycamptothecin in vivo, we prepared 10\u2010hydroxycamptothecin\u2010tetrandrine liposome complexes with 10\u2010hydroxycamptothecin as the basic anticancer drug, tetrandrine and liposomes as carriers. In this article, an ultra\u2010high performance liquid chromatography tandem mass spectrometry method for the analysis of 10\u2010hydroxycamptothecin and tetrandrine in plasma has been developed, validated, and utilized to compare the pharmacokinetics of both drugs in the original dosage form and administered as liposome complexes. According to the pharmacokinetic parameters of mean residence time, half\u2010life period and clearance rate, the 10\u2010hydroxycamptothecin\u2010tetrandrine liposome complexes prolongs the retention and circulation time of 10\u2010hydroxycamptothecin in vivo, achieving a good sustained release effect. To the best of our current knowledge, the pharmacokinetic properties of 10\u2010hydroxycamptothecin\u2010tetrandrine liposome complexes in rats have not been reported yet. Our study can provide a helpful reference for further related study.<\/jats:p>","DOI":"10.1002\/jssc.201900347","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T23:08:25Z","timestamp":1573168105000},"page":"569-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacokinetics of 10\u2010hydroxycamptothecin\u2013tetrandrine liposome complexes in rat by a simple and sensitive ultra\u2010high performance liquid chromatography with tandem mass spectrometry"],"prefix":"10.1002","volume":"43","author":[{"given":"Ruonan","family":"Shuang","sequence":"first","affiliation":[{"name":"College of Pharmacy Jiangxi University of Traditional Chinese Medicine  Nanchang P. R. 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