{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:38:29Z","timestamp":1760920709621,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173520","81803687"],"award-info":[{"award-number":["81173520","81803687"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2018\u2010JYBZZ\u2010XJSJJ007"],"award-info":[{"award-number":["2018\u2010JYBZZ\u2010XJSJJ007"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Menthae Haplocalycis<\/jats:italic> Herba has been utilized for food and medicinal purposes in China for thousands of years. It has various efficacies, including dispelling wind and heat and relieving sore throat. <jats:italic>M. Haplocalycis<\/jats:italic> Herba has been also widely used in food, cosmetics, spices, and other fields. Exploring the constituents and detecting the metabolites of <jats:italic>M. Haplocalycis<\/jats:italic> are of great significance to clarify the effective substances. However, the in vivo metabolites of <jats:italic>M. Haplocalycis<\/jats:italic> Herba water extract are still unclear. Herein, a sensitive and specific method, ultra\u2010high performance liquid chromatography with linear ion trap\u2010Orbitrap mass spectrometry, established in this assay was used to study the metabolism of <jats:italic>M. Haplocalycis<\/jats:italic> Herba water extract in rat plasma, urine, and feces. We characterized and identified 9, 50, and 34 metabolites in plasma, urine, and feces, respectively. Seven metabolic pathways, including phase \u2160 (isomerization, demethylation, hydroxylation, and dehydration) and phase \u2161 (sulfation and glucuronidation) were mainly involved in the metabolism. It is the first systematic study on the metabolism of <jats:italic>M. Haplocalycis<\/jats:italic> Herba water extract in vivo, which enrich current understanding of the metabolic behavior of <jats:italic>M. Haplocalycis<\/jats:italic> Herba water extract and provide a metabolic rationale for further in\u2010depth in vivo biotransformation and pharmacokinetic analysis.<\/jats:p>","DOI":"10.1002\/jssc.201900960","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T10:26:56Z","timestamp":1577356016000},"page":"1051-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characterization and identification of the metabolites of <i>Menthae Haplocalycis<\/i> Herba water extracts in rat plasma, urine, and feces by ultra\u2010high performance liquid chromatography with linear ion trap\u2010Orbitrap mass spectrometry"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-7794","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u2010lu","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0073-498X","authenticated-orcid":false,"given":"Yan\u2010yan","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Binzhou Medical University  Yantai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"first-page":"377","volume-title":"Pharmacopoeia of People's Republic of China, Part I","year":"2015","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","first-page":"1484","article-title":"Research progress of chemical compositions and pharmacological actions of Mentha Canadensis","volume":"30","author":"Shen M. F.","year":"2012","journal-title":"Chin. Arch. Tradit. Chin. 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