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Herein, a magnetic molecularly imprinted solid\u2010phase extraction was tailor made for selective determination of dihydroquercetin in <jats:italic>Larix griffithiana<\/jats:italic> using high\u2010performance liquid chromatography. Amino\u2010functionalized core\u2010shell magnetic nanoparticles were prepared and characterized using scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, and infrared spectroscopy. The polymer had an average diameter of 250 \u00b1 2.56\u00a0nm and exhibited good stability and adsorption for template molecule, which is enriched by hydrogen bonding interaction. Multiple factors for extraction, including loading, washing, elution solvents, and extraction time, were optimized. The limit of detection was 1.23 \u03bcg\/g. The precision determined at various concentration of dihydroquercetin was less than 4% and the mean recovery was between 74.64 and 101.80%. It has therefore been shown that this protocol can be used as an alternative extraction to quantify dihydroquercetin in <jats:italic>L. griffithiana<\/jats:italic> and purify quercetin flavonoid from other complex matrices.<\/jats:p>","DOI":"10.1002\/jssc.201901086","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T08:57:24Z","timestamp":1584608244000},"page":"2301-2310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Magnetic molecularly imprinted specific solid\u2010phase extraction for determination of dihydroquercetin from <i>Larix griffithiana<\/i> using HPLC"],"prefix":"10.1002","volume":"43","author":[{"given":"Xingbin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine Guangdong Ocean University  Zhanjiang Guangdong P. R. 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