{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:17:11Z","timestamp":1762157831261,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Program for Changjiang Scholars and Innovative Research Team in University of China"},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81603259"],"award-info":[{"award-number":["81603259"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Key Project of Research and Development Plan of Shaanxi","award":["2018SF-293"],"award-info":[{"award-number":["2018SF-293"]}]},{"name":"the Research Project of Traditional Chinese Medicine Bureau of Guangdong Province","award":["20182131"],"award-info":[{"award-number":["20182131"]}]},{"name":"the Natural Science Basic Research Plan in Shaanxi Province of China","award":["2019JQ-725"],"award-info":[{"award-number":["2019JQ-725"]}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A combination of <jats:italic>Angelicae Dahuricae Radix<\/jats:italic> and <jats:italic>Acori Tatarinowii Rhizoma<\/jats:italic> has been widely used as the herb pair in traditional Chinese medicine to treat stroke, migraine, and epilepsy. However, the underlying synergistic mechanism of the herb pair remains unknown. This study was aimed at investigating the effects of <jats:italic>Acori Tatarinowii Rhizoma<\/jats:italic> volatile oil on the pharmacokinetic parameters of xanthotoxol, oxypeucedanin hydrate, and byakangelicin from <jats:italic>Angelicae Dahuricae Radix<\/jats:italic> in rat, and in vitro absorption behavior of the three compounds using rat everted gut sac, in situ single\u2010pass intestinal perfusion, and Caco\u20102 cell monolayer models. The pharmacokinetic study exhibited clear changes in the key pharmacokinetic parameters of the three main coumarins through co\u2010administering with <jats:italic>Acori Tatarinowii Rhizoma<\/jats:italic> volatile oil (50\u00a0mg\/kg), the area under curve and the maximum plasma concentration of xanthotoxol increased 1.36 and 1.31 times; the area under curve, the maximum plasma concentration, mean residence time, half\u2010life of elimination, and the time to reach peak concentration of oxypeucedanin hydrate increased by 1.35, 1.18, 1.24, 1.19 and 1.49 times, respectively; the area under curve, mean residence time, half\u2010life of elimination, and time to reach peak concentration of byakangelicin climbed 1.29, 1.27, 1.37, and 1.28 times, respectively. The three coumarin components were absorbed well in the jejunum and ileum in the intestinal perfusion model, when co\u2010administered with <jats:italic>Acori Tatarinowii Rhizoma<\/jats:italic> volatile oil (100 \u03bcg\/mL). The in vivo and in vitro experiments showed good relevance and consistency. The results demonstrated that the three coumarin compounds from <jats:italic>Angelicae Dahuricae Radix<\/jats:italic> were absorbed through the active transportation, and <jats:italic>Acori Tatarinowii Rhizoma<\/jats:italic> volatile oil could promote the intestinal absorption and transport of these compounds by inhibiting P\u2010glycoprotein (P\u2010gp)\u2010mediated efflux.<\/jats:p>","DOI":"10.1002\/jssc.201901250","type":"journal-article","created":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T02:02:05Z","timestamp":1585360925000},"page":"2349-2362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of co\u2010administration of <i>Acori Tatarinowii Rhizoma<\/i> volatile oil on pharmacokinetic fate of xanthotoxol, oxypeucedanin hydrate, and byakangelicin from <i>Angelicae Dahuricae Radix<\/i> in rat"],"prefix":"10.1002","volume":"43","author":[{"given":"Baimei","family":"Shi","sequence":"first","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education\/College of Life Science Northwest University  Xi'an 710069 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen Longhua District Central Hospital  Shenzhen 518110 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education\/College of Life Science Northwest University  Xi'an 710069 P. R. China"},{"name":"District Traditional Chinese Medicine Hospital of Xi'an Shaanxi Province  Xi'an 710100 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4271-0302","authenticated-orcid":false,"given":"Shixiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education\/College of Life Science Northwest University  Xi'an 710069 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9967-9302","authenticated-orcid":false,"given":"Pu","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education\/College of Life Science Northwest University  Xi'an 710069 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liujiao","family":"Bian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education\/College of Life Science Northwest University  Xi'an 710069 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0738-4943","authenticated-orcid":false,"given":"Xiaohui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education\/College of Life Science Northwest University  Xi'an 710069 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,23]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"24","volume-title":"The Famous Herb\u2010Pairs Of Wind\u2010Stroke Syndrome","author":"Li W. 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