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In this method, a tablet composed of citric acid, sodium carbonate, and 1\u2010undecanol was utilized. The resulting effervescent tablet generated carbon dioxide in situ to disperse 1\u2010undecanol in the sample. Thus, the dispersive and extraction processes were performed in one synchronous step. An aliquot of acetonitrile as the demulsifier solvent was used for the separation of two phases instead of centrifugation. Under optimal conditions, the developed method was linear up to 50\u00a0000\u00a0\u00b5g\/L with correlation coefficients higher than 0.99. Moreover, limits of detection and limits of the quantification were in the range of 3\u201010\u00a0 and 7\u201030\u00a0\u00b5g\/L in water and biological samples, respectively. Intra\u2010 and interday precisions (n\u00a0=\u00a06) of the spiked methadone at a concentration level of 50\u00a0\u00b5g\/L were over ranges of 5.1\u20106.8% and 5.7\u20107.1%, respectively. The preconcentration factors and recovery values were obtained in the range of 140\u2010145 and 98.1 to 101.6% in real samples, respectively.<\/jats:p>","DOI":"10.1002\/jssc.202000078","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T17:19:10Z","timestamp":1591982350000},"page":"3266-3274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effervescent tablet\u2010assisted demulsified dispersive liquid\u2013liquid microextraction based on solidification of floating organic droplet for determination of methadone in water and biological samples prior to GC\u2010flame ionization and GC\u2010MS"],"prefix":"10.1002","volume":"43","author":[{"given":"Masoomeh","family":"Jafarinejad","sequence":"first","affiliation":[{"name":"Department of Toxicology &amp; Pharmacology Faculty of Pharmacy Pharmaceutical Sciences Branch Islamic Azad University (IAUPS)  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Ezoddin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Payame Noor University  P.O. 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