{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T03:46:22Z","timestamp":1772250382916,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Citicoline and piracetam were subjected separately to different stress conditions as recommended by the international conference on harmonization. In addition, new stability indicating thin layer chromatographic and ultra high performance liquid chromatographic methods have been developed and validated for simultaneous determination of citicoline and piracetam in presence of their degradation products. Separation on the proposed thin layer chromatographic method was carried out using a developing system containing methanol:chloroform:ammonium chloride buffer (9:1:2, v\/v\/v) on silica gel plates at 230\u00a0nm. On the other hand, the mobile phase in the ultra high performance liquid chromatographic method was composed of water (containing 0.1% triethylamine):ethanol (92:8, v\/v). The flow rate was 1\u00a0mL\/min and ultraviolet detection was at 230\u00a0nm. Moreover, results of the developed methods were statistically compared to those obtained by the reported high\u2010performance liquid chromatography method and no significant difference between them was found. The greenness profile of ultra high performance liquid chromatographic method was assessed and compared with those of the previously published high\u2010performance liquid chromatography methods, it was noticed that the proposed ultra high performance liquid chromatographic method more environmentally friendly and greener than other methods.<\/jats:p>","DOI":"10.1002\/jssc.202000346","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T05:12:53Z","timestamp":1589951573000},"page":"2981-2988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Development and validation of stability indicating chromatographic methods for simultaneous determination of citicoline and piracetam"],"prefix":"10.1002","volume":"43","author":[{"given":"Maha M.","family":"Abdelrahman","sequence":"first","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"},{"name":"Pharmaceutical Chemistry Faculty of Pharmacy Nahda University  Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1173-4654","authenticated-orcid":false,"given":"Amal B.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Faculty of Pharmacy Nahda University  Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud A.","family":"Omar","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Faculty of Pharmacy Minia University  Minia Egypt"},{"name":"Pharmacognosy and Pharmaceutical Chemistry Department College of Pharmacy Taibah University  Medina Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayed M.","family":"Derayea","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Faculty of Pharmacy Minia University  Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada S.","family":"Abdelwahab","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"},{"name":"Pharmaceutical Chemistry Faculty of Pharmacy Nahda University  Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"The Merck Index: An Encyclopedia of Chemicals, Drugs and Biological","author":"Budavaried S.","year":"2006"},{"key":"e_1_2_8_3_1","volume-title":"Martindale: The Complete Drug Reference","author":"Brayfield A.","year":"2012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1556\/1006.2015.28.3.8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5186.90892"},{"key":"e_1_2_8_6_1","first-page":"794","article-title":"Development and validation of a RP\u2010HPLC method for determination of citicoline monosodium in human plasma","volume":"30","author":"Bindaiya S. 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