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The samples were purified with optimized Quick, Easy, Cheap, Effective, Rugged, Safe methods. The amounts of primary\u2010secondary amine, C18, and sodium acetate adsorbent materials were optimized by response surface method to obtain the best purification effect. The chromatographic separation was carried out using the XBridge\u2010C18 (2.1\u00a0\u00d7\u00a0100\u00a0mm, 3.5 \u00b5m, Waters) column with mobile phase of acetonitrile with 0.1% v\/v formic acid\u2010water solutions (containing 10\u00a0mmol\/L ammonium acetate), separated by gradient elution. The instrument was operated in the detection mode of electrospray positive and negative ions with Full MS\/data dependent MS<jats:sup>2<\/jats:sup> acquisition mode detection, external standard method was used for quantitative analysis. The limits of detection and limits of quantitation of 31 compounds were 0.1\u20130.5 \u00b5g\/L and 0.5\u20132.0 \u00b5g\/L, respectively. A total of 31 compounds performed a good linearity in the range of 1 to 200 \u00b5g\/L, and the correlation coefficient was greater than 0.990. The spiked recoveries in milk samples were 81.07\u2013110.1% and the relative standard deviation was less than 5.1%. The method was successful applied to actual sample testing in the market.<\/jats:p>","DOI":"10.1002\/jssc.202000408","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T11:41:29Z","timestamp":1596022889000},"page":"3719-3734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Targeted analysis of six emerging derivatives or metabolites together with 25 common macrolides in milk using Quick, Easy, Cheap, Effective, Rugged and Safe extraction and ultra\u2010performance liquid chromatography quadrupole\/electrostaticfield orbitrap mass spectrometry"],"prefix":"10.1002","volume":"43","author":[{"given":"Jia","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Food Safety Chinese Academy of Inspection &amp; Quarantine  Beijing P. R. China"},{"name":"School of Pharmacy Jinzhou Medical University  Jinzhou Liaoning P. R. 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