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Deep eutectic solvents consist of methyltrioctylammonium chloride and various medium\u2010chain alcohols\/acids, and are easy in preparation, low cost and toxicity, desirably biodegradable, and biocompatible. The\u00a0overall\u00a0time\u00a0required for sample preparation was 6\u00a0min and the volume of organic solvent used for extraction was only 400\u00a0\u00b5L. Under the optimized extraction condition, the present method yielded low limit of detection (0.5\u20132.0\u00a0ng\/mL), acceptable precision (relative standard deviations &lt; 9.7%), good linearity from 2.0 to 500\u00a0ng\/mL (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0\u2265\u00a00.9991). This optimized procedure was applied for determination of tetracyclines in different water samples with desirable spiked recovery ranged from 77.5 to 87.6%. There is, therefore, a great potential to further expand application of the method for investigation of other ultra\u2010trace analyte(s) in environmental matrixes.<\/jats:p>","DOI":"10.1002\/jssc.202000477","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T10:21:36Z","timestamp":1591525296000},"page":"3129-3135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hydrophobic deep eutectic solvent as a green extractant for high\u2010performance liquid chromatographic determination of tetracyclines in water samples"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0428-7323","authenticated-orcid":false,"given":"Xin","family":"Di","sequence":"first","affiliation":[{"name":"College of Pharmacy Ningxia Medical University  Yinchuan P. R. 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