{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:06:12Z","timestamp":1773479172430,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007136","name":"Secretar\u00eda de Estado de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["AGL2015\u201070708\u2010R"],"award-info":[{"award-number":["AGL2015\u201070708\u2010R"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new analytical method based on capillary liquid chromatography with diode array detection has been developed for the simultaneous quantification of seven neonicotinoid insecticides commercially available (imidacloprid, thiacloprid, clothianidin, thiamethoxam, acetamiprid, nitenpyram, and dinotefuran) in honey samples. The separation was achieved in a Zorbax XDB\u2010C18 column (150\u00a0\u00d7\u00a00.5\u00a0mm id, 5\u00a0\u03bcm), with a mobile phase consisting of ultrapure water (solvent A) and acetonitrile (solvent B) at a flow rate of 10 \u03bcL\/min. Capillary column was thermostated at 25\u00b0C during the analysis and 254 or 270\u00a0nm was established as detection wavelength, depending on the analyte. Furthermore, full loop injection mode (8 \u03bcL) was selected, using water as injection solvent. Finally, the optimized method was applied to the analysis of neonicotinoid residues in honey of different floral origins using dispersive liquid\u2013liquid microextraction as sample treatment. Variables affecting the extraction efficiency were optimized, choosing methanol and dichloromethane as dispersive and extraction solvents, respectively. The method was characterized in terms of linearity (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jssc6995-math-0001.png\" xlink:title=\"urn:x-wiley:16159306:media:jssc6995:jssc6995-math-0001\"\/>\u2265 0.9948), repeatability, reproducibility (relative standard deviation below 4.5 and 6.3% respectively), and recoveries (\u226580.5%). Detection and quantification limits were lower than 6.6 and 22.0\u00a0\u03bcg\/kg for the studied analytes, respectively.<\/jats:p>","DOI":"10.1002\/jssc.202000611","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T04:26:10Z","timestamp":1597033570000},"page":"3847-3855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Capillary liquid chromatography as an effective method for the determination of seven neonicotinoid residues in honey samples"],"prefix":"10.1002","volume":"43","author":[{"given":"Laura","family":"Carbonell\u2010Rozas","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Sciences University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7172-9323","authenticated-orcid":false,"given":"Francisco J.","family":"Lara","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Sciences University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monsalud","family":"del Olmo Iruela","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Sciences University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Garc\u00eda\u2010Campa\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Sciences University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10646-012-0863-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1259159"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.125145"},{"key":"e_1_2_8_5_1","first-page":"1","article-title":"Regulation (EC) No 396\/2005 of the European Parliament and the Council of 23 February 2005 on maximum residue levels of pesticides in or on food and feed of plant and animal origin and amending Council Directive 91\/414\/EEC","volume":"70","author":"European Parliament,\u00a0Council of the European Union.","journal-title":"Off J Eur Com"},{"key":"e_1_2_8_6_1","first-page":"26","article-title":"Amending certain Annexes to Council Directives 86\/362\/EEC, 86\/363\/EEC and 90\/642\/EEC as regards maximum residue levels of acetamiprid, thiacloprid, amazosulfuron, methoxyfenozide, S\u2010metholachlor, milbemectin and tribenuron","volume":"63","author":"Commission Directive 2007\/11\/EC of 21 February 2007","journal-title":"Off J Eur Com"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":". Amending Annexes II and III to Regulation (EC) No 396\/2005 of the European Parliament and of the Council as regards maximum residue levels for ametoctradin, azoxystrobin, cycloxydim, cyfluthrin, dinotefuran, fenbuconazole, fenvalerate, fludioxonil, fluopyram, flutriafol, fluxapyroxad, glufosinateammonium, imidacloprid, indoxacarb, MCPA, methoxyfenozide, penthiopyrad, spinetoram and trifloxystrobin in or on certain products","volume":"146","author":"Commission Regulation (EU) No. 491\/2014 of 5 May 2014","journal-title":"Off J Eur Com"},{"key":"e_1_2_8_8_1","first-page":"9","article-title":"Amending Annex II to Regulation (EC) No 396\/2005 of the European Parliament and of the Council as regards maximum residue levels for clothianidin and thiamethoxam in or on certain products","volume":"97","author":"Commission Regulation (EU) 2017\/671 of 7 April 2017.","journal-title":"Off J Eur Com"},{"key":"e_1_2_8_9_1","first-page":"12","article-title":". Amending Implementing Regulation (EU) No 540\/2011, as regards the conditions of approval of the active substances clothianidin, thiamethoxam and imidacloprid, and prohibiting the use and sale of seeds treated with plant protection products containing those active substances","volume":"139","author":"Commission Implementing Regulation (EU) No. 485\/2013 of 24 May 2013","journal-title":"Off J Eur Com"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-014-3229-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan3684"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf400669b"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2014.12.021"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040883"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23051165"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201900473"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2016.06.020"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf904120n"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2011.05.026"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/03067310903524822"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2013.02.059"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.07.068"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201801163"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(03)00835-5"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1061934813050031"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1061934814010055"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.01.028"},{"key":"e_1_2_8_28_1","article-title":"Micellar electrokinetic chromatography as efficient alternative for the multiresidue determination of seven neonicotinoids and 6\u2010chloronicotinic acid in environmental samples","author":"Carbonell\u2010Rozas L.","year":"2019","journal-title":"Anal Bioanal Chem"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.07.028"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.09.088"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2014.03.042"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2019.104249"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2013.05.021"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjssc.202000611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.202000611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jssc.202000611","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.202000611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:05:01Z","timestamp":1760875501000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.202000611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,25]]},"references-count":32,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/jssc.202000611"],"URL":"https:\/\/doi.org\/10.1002\/jssc.202000611","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,25]]},"assertion":[{"value":"2020-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}