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The prepared glutathione@Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> nanocomposite was used as the sorbent in the form of magnetic solid\u2010phase extraction. Afterward, the extracted analytes were desorbed by organic solvent and analyzed by high\u2010performance liquid chromatography\u2010ultraviolet detection. Several influential variables such as desorption time, desorption volume, sample pH, extraction time, and sorbent amount were screened through Plackett\u2013Burman design and then optimized via Box\u2013Behnken design. The obtained results showed that the above\u2010mentioned method enjoys a good linear range (0.2\u2013500 \u03bcg\/L) with the coefficient of determination higher than 0.9927, low limits of determination (0.07\u20130.24 \u03bcg\/L), acceptable limits of quantification (0.22\u20130.93 \u03bcg\/L), good enrichment factors (128 and 153), and good spiking recoveries (95\u2013105%) for diazepam and sertraline under the obtained optimized condition. Analyzing the real samples results in the confirmation of the presented method and it can be applied for the analysis of various organic compounds in biological samples.<\/jats:p>","DOI":"10.1002\/jssc.202000938","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T09:23:49Z","timestamp":1604309029000},"page":"1195-1202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Glutathione\u2010stabilized Fe<sub>3<\/sub>O<sub>4<\/sub> nanoparticles as the sorbent for magnetic solid\u2010phase extraction of diazepam and sertraline from urine samples through quantitation via high\u2010performance liquid chromatography"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-1856","authenticated-orcid":false,"given":"Milad","family":"Ghani","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemistry University of 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