{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:49:15Z","timestamp":1790912955367,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Two antimalaria alkaloids, febrifugine and isofebrifugine, were successfully separated from total alkaloids of\n                      <jats:italic>Dichroa febrifuga<\/jats:italic>\n                      roots by one\u2010step preparative countercurrent chromatography with a selected biphasic solvent system. The selected biphasic solvent system was composed of chloroform: methanol: water (2:1:1, v\/v) according to partition performance of the two target components. Selection of biphasic solvent system was conducted by high performance liquid chromatography combined with high performance thin layer chromatography, which greatly assisted the screening procedure for biphasic solvent system. Totally, 50\u00a0mg of total alkaloid was separated by one\u2010step preparative countercurrent chromatography, yielding 12\u00a0mg of febrifugine and 9\u00a0mg of isofebrifugine with more than 98.0% purity, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jssc.202001257","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T08:20:55Z","timestamp":1617438055000},"page":"2153-2159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Preparative separation of two isomeric antimalaria alkaloids febrifugine and isofebrifugine from\n                    <i>Dichroa febrifuga<\/i>\n                    roots by countercurrent chromatography"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-7904","authenticated-orcid":false,"given":"Liu\u2010Qing","family":"Sheng","sequence":"first","affiliation":[{"name":"Pharmaceutical College, Jinhua Polytechnic Jinhua  Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Lei","family":"Ma","sequence":"additional","affiliation":[{"name":"Pharmaceutical College, Jinhua Polytechnic Jinhua  Zhejiang P. R. 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