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Mahuang decoction is a well\u2010known traditional Chinese medicine prescription widely used for sweating and relieving the exterior, relieving cough and asthma, but it was insufficiently chemically scrutinized. In this study, the chemical component information of Mahuang decoction was investigated by ultrahigh\u2010performance liquid chromatography tandem linear ion trap\u2010Orbitrap mass spectrometry. A new data processing tool, feature\u2010based molecular networking, was introduced for grouping and elucidating the compounds. In this way, 156 chemical components were identified or tentatively characterized, including alkaloids, triterpenoid saponins, flavanone\u2010<jats:italic>O<\/jats:italic>\u2010glycosides, flavone\u2010<jats:italic>C<\/jats:italic>\u2010glycosides, and procyanidins. Thus, this research provides a solid foundation for further development of Mahuang decoction, and the adopted method is expected to be applied to other traditional Chinese medicine prescriptions.<\/jats:p>","DOI":"10.1002\/jssc.202100121","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T02:07:49Z","timestamp":1620526069000},"page":"2717-2727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap\u2010Orbitrap mass spectrometry coupled with feature\u2010based molecular networking"],"prefix":"10.1002","volume":"44","author":[{"given":"Ling","family":"Chen","sequence":"first","affiliation":[{"name":"School of Pharmacy Nanjing University of Chinese Medicine  Nanjing P. R. 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