{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:05:48Z","timestamp":1789239948996,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human exposure to bisphenols has rarely been reported. The most important challenges in this regard are the sensitivity and accuracy of the analytical methods employed. Dansyl chloride derivatization prior to high\u2010performance liquid chromatography\u2013tandem mass spectrometry has been prevalently employed to improve sensitivity. However, the dose effect of the derivatization reagent on the reaction products is not well understood, especially for reactants with two or more active groups. This study investigated the mass ratio of dansyl chloride to bisphenols and found the mass ratio played a vital role in changing the composition of derivatives; further, the optimal ratio for obtaining di\u2010substituted derivatives was confirmed. Under optimal conditions, solid\u2010phase extraction followed by dansyl chloride derivatization coupled with high\u2010performance liquid chromatography\u2013tandem mass spectrometry was used to detect eight bisphenols in human serum samples. The method detection limits of the eight bisphenols were 0.025\u20120.28\u00a0ng\/mL, and the recoveries were 72.9\u2012121.7% by spiking bisphenols (2, 5, and 20\u00a0ng\/mL) into bovine serum. The detection frequencies of bisphenol A and bisphenol F in 73 serum samples obtained from children from Guangzhou were 41.1% and 71.2%, respectively, while the detection frequencies of other bisphenols were below 20%. The concentrations of bisphenol A and bisphenol F were\u00a0&lt;\u00a00.28\u20128.0\u00a0ng\/mL and\u00a0&lt;\u00a00.028\u20127.6\u00a0ng\/mL, respectively.<\/jats:p>","DOI":"10.1002\/jssc.202100171","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T21:01:58Z","timestamp":1623186118000},"page":"3052-3060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The dose effect of dansyl chloride on the derivative products of bisphenols and its application for the determination of bisphenols in human serum by high\u2010performance liquid chromatography\u2013tandem mass spectrometry"],"prefix":"10.1002","volume":"44","author":[{"given":"Cuicui","family":"Guo","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian Liaoning P. R. 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