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The maximum extraction efficiencies were obtained using 400 \u03bcL of [choline chloride]:[thymol]:[nonanoic acid] in the molar ratio of 1:2:2 at pH = 5. The solvent was characterized by FTIR and NMR spectroscopy. The hydrophobicity of the deep eutectic solvent and its effect on the pH of water samples after mixing was also studied. Besides, the extraction efficiency of the ternary deep eutectic solvent was compared with that of two binary thymol\u2010based deep eutectic solvents, including [choline chloride]:[thymol] and [thymol]:[nonanoic acid] at the same conditions. Under optimal conditions, limits of detection and quantification were 1.2\u20138.0 and 3.8\u201326.6\u00a0\u03bcg\/L, respectively. The linear ranges were 18.2\u2013500\u00a0\u03bcg\/L for oxytetracycline, 26.6\u2013500\u00a0\u03bcg\/L for tetracycline, and 3.8\u2013500\u00a0\u03bcg\/L for doxycycline with the determination coefficients\u00a0&gt;\u00a00.9912. Intra\u2010 and inter\u2010day relative standard deviations were 1.2\u20133.8 and 7.7\u201311.2%, respectively. The developed method was applied to the analysis of tetracyclines in unspiked and spiked environmental water samples, and the obtained recoveries were 74.5\u201395.4% with relative standard deviations of 1.2\u20134.0%.<\/jats:p>","DOI":"10.1002\/jssc.202100495","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T06:57:37Z","timestamp":1628233057000},"page":"3626-3635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Natural thymol\u2010based ternary deep eutectic solvents: Application in air\u2010bubble assisted\u2010dispersive liquid\u2010liquid microextraction for the analysis of tetracyclines in water"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6300-1954","authenticated-orcid":false,"given":"Hassan","family":"Sereshti","sequence":"first","affiliation":[{"name":"School of Chemistry, College of Science University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazaleh","family":"Abdolhosseini","sequence":"additional","affiliation":[{"name":"School of Chemistry, College of Science University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Soltani","sequence":"additional","affiliation":[{"name":"School of Chemistry, College of Science University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"School of Chemistry, College of Science University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Nouri","sequence":"additional","affiliation":[{"name":"School of Chemistry, College of Science University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"The antibiotic paradox","author":"Levy SB","year":"2002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/es048603o"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2018.03.038"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ra43385d"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2012.12.032"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.06.064"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201500497"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2014.04.105"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1061934815030211"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-018-1475-y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2018.04.030"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.10851"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202000477"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.105269"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.105914"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.11.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2018.06.049"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-020-04320-w"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.104988"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2012.03.031"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.02.033"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/15422119.2018.1460851"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2019.115734"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/sc5001594"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2019.01.126"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.12.106"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.0c04839"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/sc500096j"},{"key":"e_1_2_9_30_1","first-page":"1000133","article-title":"Experimental measurements of octanol\u2010water partition coefficients of ionic liquids","volume":"5","author":"Montalb\u00e1n M.G.","year":"2015","journal-title":"J. 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