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However, the wide particle size distribution and irregular shape of as\u2010synthesized metal\u2013organic frameworks result in low column efficiency, undesired chromatographic peak shape, and high column backpressure of such metal\u2013organic frameworks packed columns. Herein, we report the fabrication of chiral core\u2010shell microspheres [Cu<jats:sub>2<\/jats:sub>(<jats:sc>d<\/jats:sc>\u2010Cam)<jats:sub>2<\/jats:sub>(4,4\u2032\u2010bpy)]<jats:sub>n<\/jats:sub>@SiO<jats:sub>2<\/jats:sub> composite for high\u2010performance liquid chromatography enantioseparation to overcome the above\u2010mentioned problems. The [Cu<jats:sub>2<\/jats:sub>(<jats:sc>d<\/jats:sc>\u2010Cam)<jats:sub>2<\/jats:sub>(4,4\u2032\u2010bpy)]<jats:sub>n<\/jats:sub>@SiO<jats:sub>2<\/jats:sub> packed column gave high\u2010resolution separation of racemates under low column backpressure (10\u201022\u00a0bar), indicating its synergistic effect of the good column packing property of the SiO<jats:sub>2<\/jats:sub> microspheres and the chiral recognition ability of [Cu<jats:sub>2<\/jats:sub>(<jats:sc>d<\/jats:sc>\u2010Cam)<jats:sub>2<\/jats:sub>(4,4\u2032\u2010bpy)]<jats:sub>n<\/jats:sub> crystals. Thirteen kinds of chiral compounds including alcohols, amines, ketones, epoxides, and organic bases were well separated with good peak shapes and high column efficiency (18200 plates\/m for 1\u2010(9\u2010anthryl)\u20102,2,2\u2010trifluoroethanol) on the [Cu<jats:sub>2<\/jats:sub>(<jats:sc>d<\/jats:sc>\u2010Cam)<jats:sub>2<\/jats:sub>(4,4\u2032\u2010bpy)]<jats:sub>n<\/jats:sub>@SiO<jats:sub>2<\/jats:sub> packed column. Among them, seven pairs of enantiomers achieved baseline separation and the resolution value for 1\u2010(9\u2010anthryl)\u20102,2,2\u2010trifluoroethanol reached 11.22. Some effects such as column temperature, and analytes mass on the enantioseparations have been investigated. In addition, the [Cu<jats:sub>2<\/jats:sub>(<jats:sc>d<\/jats:sc>\u2010Cam)<jats:sub>2<\/jats:sub>(4,4\u2032\u2010bpy)]<jats:sub>n<\/jats:sub>@SiO<jats:sub>2<\/jats:sub> packed column exhibited good stability and repeatability for the separation of chiral compounds. The relative standard deviations for five replicate separations of 1\u2010phenylethanol were less than 1.0, 1.5, 3.0, and 2.0% for the retention time, peak area, number of theoretical plates, and resolution, respectively. The research results demonstrated the development of chiral metal\u2013organic frameworks core\u2010shell microspheres composite provide a promising platform for their practical application in chiral separation fields.<\/jats:p>","DOI":"10.1002\/jssc.202100557","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T07:39:49Z","timestamp":1631000389000},"page":"3976-3985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A chiral metal\u2010organic framework core\u2010shell microspheres composite for high\u2010performance liquid chromatography enantioseparation"],"prefix":"10.1002","volume":"44","author":[{"given":"Ji\u2010Kai","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Chemistry Yunnan Normal University  Kunming P.R. 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