{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:17:06Z","timestamp":1780604226758,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2019ZX09201004\u2010003\u2010042"],"award-info":[{"award-number":["2019ZX09201004\u2010003\u2010042"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Wine\u2010processed <jats:italic>Angelica Sinensis<\/jats:italic> is a widely used Chinese medicinal decoction piece in China. However, there are hardly any robust markers indicating the processing procedure of wine\u2010processed <jats:italic>Angelica Sinensis<\/jats:italic>, including the amount of rice wine and processing degree. A strategy integrating untargeted metabolomics and chemometric analysis for deducing robust markers was provided and applied to the discrimination of processing procedure. First, 86 compounds were tentatively identified in wine\u2010processed <jats:italic>Angelica Sinensis<\/jats:italic> by ultra\u2010high\u2010performance liquid chromatography coupled with quadrupole\u2010time of flight mass spectrometry. Second, 93 potential chemical markers were selected using multivariate analysis, among which nine robust chemical markers were selected by verification with commercial samples. Finally, the effects of processing temperature, time, and amount of rice wine on the three selected chemical markers were investigated through a rapid analytical method. It was demonstrated that both <jats:italic>m\/z<\/jats:italic> 258.1097 and 238.1189 were positively correlated with the amount of rice wine and processing degree. In summary, this study introduced two candidate processing markers as robust markers for discriminating the processing procedures of wine\u2010processed <jats:italic>Angelica sinensis<\/jats:italic>. It also proposed a strategy to provide the reference for the research of other decoction pieces.<\/jats:p>","DOI":"10.1002\/jssc.202100566","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T13:10:41Z","timestamp":1631452241000},"page":"4092-4110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Untargeted metabolomics coupled with chemometric analysis deducing robust markers for discrimination of processing procedures: Wine\u2010processed <i>Angelica sinensis<\/i> as a case study"],"prefix":"10.1002","volume":"44","author":[{"given":"Haoran","family":"Yin","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing P. R. 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