{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:39:00Z","timestamp":1792625940928,"version":"4.5.0"},"reference-count":85,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020\u2010118924RB\u2010I00"],"award-info":[{"award-number":["PID2020\u2010118924RB\u2010I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dispersive liquid\u2010liquid microextraction is one of the most widely used microextraction techniques currently in the analytical chemistry field, mainly due to its simplicity and rapidity. The operational mode of this approach has been constantly changing since its introduction, adapting to new trends and applications. Most of these changes are related to the nature of the solvent employed for the microextraction. From the classical halogenated solvents (e.g., chloroform or dichloromethane), different alternatives have been proposed in order to obtain safer and non\u2010pollutants microextraction applications. In this sense, low\u2010density solvents, such as alkanols, switchable hydrophobicity solvents, and ionic liquids were the first and most popular replacements for halogenated solvents, which provided similar or better results than these classical dispersive liquid\u2010liquid microextraction solvents. However, despite the good performances obtained with low\u2010density solvents and ionic liquids, researchers have continued investigating in order to obtain even greener solvents for dispersive liquid\u2010liquid microextraction. For that reason, in this review, the evolution over the last five years of the three types of solvents already mentioned and two of the most promising solvent alternatives (i.e., deep eutectic solvents and supramolecular solvents), have been studied in detail with the purpose of discussing which one provides the greenest alternative.<\/jats:p>","DOI":"10.1002\/jssc.202100609","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T02:50:05Z","timestamp":1630983005000},"page":"210-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Use of green alternative solvents in dispersive liquid\u2010liquid microextraction: A review"],"prefix":"10.1002","volume":"45","author":[{"given":"Jos\u00e9","family":"Grau","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry GICAPC Research group University of Valencia  Burjassot Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3472-6857","authenticated-orcid":false,"given":"Cristian","family":"Azor\u00edn","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry GICAPC Research group University of Valencia  Burjassot Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan L.","family":"Bened\u00e9","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry GICAPC Research group University of Valencia  Burjassot Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-0478","authenticated-orcid":false,"given":"Alberto","family":"Chisvert","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry GICAPC Research group University of Valencia  Burjassot Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-4076","authenticated-orcid":false,"given":"Amparo","family":"Salvador","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry GICAPC Research group University of Valencia  Burjassot Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2014.12.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2019.104386"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.03.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2018.11.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2019.07.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2017.04.012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.09.111"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2006.12.049"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.127943"},{"key":"e_1_2_9_11_1","first-page":"1","article-title":"Conclusion on the peer review of the pesticide risk assessment of the active substance 1\u2010decanol","volume":"8","author":"Food E","year":"2010","journal-title":"EFSA J"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.116025"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.105115"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac60312a009"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.12.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.120587"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2020.461041"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2017.04.066"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201901078"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3GC42164C"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287399109531485"},{"key":"e_1_2_9_22_1","unstructured":"ZeigerE.Review of toxicological literature. Integrated laboratory systems.1997;1\u201363."},{"key":"e_1_2_9_23_1","unstructured":"Regulation (EU) no 528\/2012 concerning the making available on the market and use of biocidal products. Assesment Report: Octanoic acid;2012."},{"key":"e_1_2_9_24_1","unstructured":"Regulation (EU) no 528\/2012 concerning the making available on the market and use of biocidal products. Assesment Report: Decanoic acid;2012."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2009.11.009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201200486"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.115994"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2013.06.008"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.11.076"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.115833"},{"key":"e_1_2_9_31_1","volume-title":"Ionic liquids in analytical chemistry","author":"Carda\u2010Broch S","year":"2021"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2019.07.025"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.12.078"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac071555g"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200800308"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-008-0092-4"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2018.03.001"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/b314754a"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/B006677J"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/B915049H"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2010.07.027"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-020-02559-y"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.06.029"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201600263"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2021.116231"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA07780G"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2016.11.026"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2018.10.041"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2019.01.030"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.03.049"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2019.111768"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2020.461777"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2015.09.019"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs35178a"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.121507"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.105539"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2019.104384"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201600633"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5AY03189C"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201700890"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2017.07.053"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201700052"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201701282"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.10.135"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.4319"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2019.03.003"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2020.08.022"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2019.03.038"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2019.06.050"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2gc35660k"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.104837"},{"key":"e_1_2_9_72_1","first-page":"2120","article-title":"Preparation of a new polymeric deep eutectic solvent and its application in vortex\u2010assisted liquid\u2010liquid microextraction of parabens in foods, cosmetics and pharmaceutical products","volume":"31","author":"Ge D","year":"2020","journal-title":"J Braz Chem Soc."},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.113766"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2020.461523"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2019.460695"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0AY00073F"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202001183"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.113015"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.12.005"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2016.03.109"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2003.08.027"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.11.256"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.114888"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2020.07.024"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA07300G"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.120209"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.202100609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jssc.202100609","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.202100609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:36:33Z","timestamp":1760866593000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.202100609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,22]]},"references-count":85,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/jssc.202100609"],"URL":"https:\/\/doi.org\/10.1002\/jssc.202100609","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,22]]},"assertion":[{"value":"2021-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}