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Therefore, it is necessary to investigate whether the oral bioavailability of cinnarizine can be improved after co\u2010administration with precipitation inhibitors or not. In order to evaluate the pharmacokinetic behavior of cinnarizine in rats, a simple, rapid, sensitive, and environmentally friendly supercritical fluid chromatography\u2010tandem mass spectrometric method was established and validated. In this method, flunarizine, a structural analogue of cinnarizine, was selected as the internal standard, and cinnarizine was extracted from rat plasma using evaporation\u2010free liquid\u2013liquid extraction method. The analytes were separated on a Torus 1\u2010AA column (3.0\u00a0mm \u00d7 100\u00a0mm, 1.7 \u03bcm) within 2.0\u00a0min, using a gradient elution procedure. The transitions of cinnarizine and flunarizine were <jats:italic>m\/z<\/jats:italic> 369.1 \u2192 167.1 and <jats:italic>m\/z<\/jats:italic> 405.1 \u2192 203.1, respectively. Cinnarizine showed good linear correlation in the range of 1\u2013500\u00a0ng\/ml with a lower limit of quantification of 1\u00a0ng\/ml. The intra\u2010 and interday precision and accuracy of all quality control samples were within \u00b115%. This high\u2010throughput, accurate, sensitive, and reproducible method has been successfully applied to study the effects of the precipitation inhibitor cinnarizine on the pharmacokinetics in rats.<\/jats:p>","DOI":"10.1002\/jssc.202100825","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T01:45:55Z","timestamp":1639100755000},"page":"968-975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Supercritical fluid chromatography tandem mass spectrometry employed with evaporation\u2010free liquid\u2013liquid extraction for the rapid analysis of cinnarizine in rat plasma"],"prefix":"10.1002","volume":"45","author":[{"given":"Jiaming","family":"Zhang","sequence":"first","affiliation":[{"name":"Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang 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