{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:55:59Z","timestamp":1787892959348,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T00:00:00Z","timestamp":1639872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A comparative study of chiral separation of pantoprazole and rabeprazole is carried out using supercritical fluid chromatography and high\u2010performance liquid chromatography. The columns used were Chiralpak IA and Chiralpak IE. The best mobile phase in supercritical fluid chromatography was carbon dioxide\u20100.2% triethylamine in methanol (60:40) and 0.1% triethylamine in <jats:italic>n<\/jats:italic>\u2010hexane\u2010ethanol (50:50) in high\u2010performance liquid chromatography. For supercritical fluid chromatography, values of the retention factor of pantoprazole enantiomers were 3.97 and 4.88. These values for rabeprazole enantiomers were 6.10 and 7.52. The values of separation and resolution factor for pantoprazole and rabeprazole were 1.23 and 1.23 and 2.20 and 3.36, respectively. Similarly, for high\u2010performance liquid chromatography, the values of retention factor for enantiomers of pantoprazole were 4.02 and 7.32. These values for rabeprazole enantiomers were 5.32 and 7.88, respectively. The values of separation and resolution factor for pantoprazole and rabeprazole were 1.82 and 1.48 and 9.22 and 6.58, respectively. A comparison was carried out, which confirmed supercritical fluid chromatography as the best method due to its fastness, eco\u2010friendly, and inexpensiveness. The reported methods are effective, efficient, and reproducible and may be used to separate and identify pantoprazole and rabeprazole in any unknown samples.<\/jats:p>","DOI":"10.1002\/jssc.202100834","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T19:30:06Z","timestamp":1639164606000},"page":"804-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A comparative study of chiral separation of proton <i>pump<\/i> inhibitors by supercritical fluid chromatography and high\u2010performance liquid chromatography"],"prefix":"10.1002","volume":"45","author":[{"given":"Rupak","family":"Raja","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Basic and Applied Sciences Galgotias University  Greater Noida India"},{"name":"Jubilant Biosys Limited  Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Dilshad","family":"Alam","sequence":"additional","affiliation":[{"name":"Jubilant Biosys Limited  Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Srisath","sequence":"additional","affiliation":[{"name":"Jubilant Biosys Limited  Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind Kumar","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Basic and Applied Sciences Galgotias University  Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeid A.","family":"ALOthman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah A. 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