{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:00:59Z","timestamp":1769763659655,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>The stem bark of <jats:italic>Magnolia officinalis<\/jats:italic> is a traditional Chinese medicine for the treatment of abdominal distention and functional dyspepsia. The pharmacokinetics of three glycosides (magnoloside A, magnoloside B, and syringin) and two lignans (honokiol and magnolol) in both normal and functional dyspepsia rats were firstly investigated by ultra\u2010performance liquid chromatography\u2010triple quadrupole mass spectrometry method and the influences of the coexisting compounds on the pharmacokinetic parameters of honokiol and magnolol were also studied. It was found that all of the five target compounds were quickly absorbed and eliminated in both normal and functional dyspepsia rats, while, their residence time was significantly decreased in pathological states except magnoloside A. The coexisting compounds in the stem bark of <jats:italic>M. officinalis<\/jats:italic> significantly reduced absorption and increased elimination of honokiol in vivo. It's worth noticing that the volume of distribution of lignan was quite lower than that of a glycoside. Moreover, the metabolic profiling of magnoloside A, honokiol, and magnolol in vivo was analyzed by ultra\u2010performance liquid chromatography\u2010quadrupole time\u2010of\u2010flight mass spectrometry method, from which three prototypes were identified and 35 metabolites were putatively characterized, and 18 unknown metabolites were reasonably characterized for the first time. The results indicated that sulfation and glucuronidation were the main metabolic pathways of honokiol and magnolol.<\/jats:p>","DOI":"10.1002\/jssc.202100982","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T08:39:39Z","timestamp":1659256779000},"page":"3663-3678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pharmacokinetics and metabolites of glycosides and lignans of the stem bark of <i>Magnolia officinalis<\/i> in functional dyspepsia and normal rats using liquid chromatography\u2010tandem mass spectrometry"],"prefix":"10.1002","volume":"45","author":[{"given":"Jidan","family":"Zhang","sequence":"first","affiliation":[{"name":"Research Center for Analytical Chemistry of Traditional Chinese Medicine Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences  Beijing 100700 P. R. 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